Plusieurs groupes de recherche sont constitués au sein du service d'Immunologie et d'Allergologie

• Groupe Pr Dr Jörg Seebach
• Groupe Dr Jean-Marie Tiercy
• Groupe Dre Sylvie Ferrari-Lacraz et Dr Jean Villard
• Groupe Dre Pascale Roux-Lombard
• Groupe Pr Carlo Chizzolini
• Groupe Dre Danielle Burger
• Groupe Dr Philippe Eigenmann
• Cohorte Suisse sur le Lupus Erythémateux Systémique

Liste des publications du service d'immunoligie et d'allergologie

Projets de recherche

• Développement de méthodes statistiques pour les méta-analyses de données de survie 
  A. Gayet-Ageron, S. Jannot, C. Combescure, A. Poncet, T. Perneger

Le but de ce projet est de développer de nouvelles méthodes statistiques permettant de synthétiser les données publiées dans différentes études de survie. Ces méthodes sont applicables aux méta-analyses. Nous proposons des méthodes pour estimer un effet d’intervention qui varie au cours du temps, une courbe ROC résumée représentant la capacité pronostique d’un marqueur continu, une courbe de survie résumée sans hypothèse sur la distribution du temps de survie.

• Utilisation des Résultats de la Recherche & Pratique de l’Evidence-Based Medicine (EBM) 
  T. Agoritsas

Le premier but de la recherche clinique est de fournir aux professionnels de la santé les données valides et pertinentes leur permettant de répondre à leurs questions cliniques concernant le traitement, diagnostic et pronostic des pathologies rencontrées (Evidence-Based Medicine). Plusieurs enjeux naissent à cette interface entre la production du savoir et son utilisation dans la pratique clinique.

• Determination of the clinically important difference to be detected in a randomized controlled trial. Electronic survey among researches. (coming soon!)
  A. Gayet-Ageron, T. Agoritsas, T. Perneger 

• What differences are detected by superiority trials or ruled out by noninferiority trials? A cross-sectional study on a random sample of two-hundred two-arms parallel group randomized clinical trials. 
  Angèle Gayet-Ageron, Thomas Agoritsas, Christophe Combescure, Krisztina Bagamery, Delphine S. Courvoisier, Thomas V. Perneger 
  BMC Med Res Methodol. 2010 Oct 15;10:93 

• Citation bias favoring statistically significant studies was present in medical research.
  A-S. Jannot, T. Agoritsas, A. Gayet-Ageron, T. Perneger. J Clin Epidemiol. 2013 Mar;66(3):296-301 PMID: 23347853

• NCCR LIVES – Overcoming Vulnerability: Life Course Perspectives
  IP 10. Health trajectories and life transitions - A life-course approach to health vulnerability 
  C. Burton-Jeangros, G. Ritschard, A. Gabadinho, D. Courvoisier, S. Cullati

This project will (1) look at the impact of intergenerational and intragenerational social mobility, and familial dis/continuity over health trajectories in comparison to life-course characterized by stability and/or immobility; (2) examine how transitions - ie events in work or/and family spheres - are potentially associated with variations in health

• Sensitivity, specificity, and likelihood ratios of polymerase chain reaction in the diagnosis of syphilis: a systematic review and meta-analysis. 
  A. Gayet-Ageron, C. Combescure, S. Lautenschlager, B. Ninet-Bescher, T. Perneger 
  Sex Trans Dis 2012. PMID:23024223.

• Patient discrimination and the medical decision process among Swiss physicians.
  A-S. Jannot, N. Junod-Perron, S. Hurst, T. Perneger

This project will examine the impact of patient characteristes medical decisions of ressource allocation using conjoint exclusis.

• La recherche clinique en milieu hospitalier: caractéristiques et productivité des protocoles de recherche soumis à la Commission d'éthique de la recherche des Hôpitaux Universitaires de Genève, 2001-2005.
  Chaque année, plusieurs centaines de projets de recherche clinique sont menés au sein des Hôpitaux Universitaires de Genève (HUG). L'objectif de cette étude est de décrire les projets en recherche clinique approuvés par la commission centrale d’éthique des HUG (design, méthodologies, population, financement, etc.), afin de comprendre dans quelle mesure les protocoles ayant été modifiés en cours d’étude (design, échantillon, analyses, etc.) ont plus de chance d’être publiés que les protocoles non modifiés.

Coordination : Thomas Agoritsas

Le premier but de la recherche clinique est de fournir aux professionnels de la santé les données valides et pertinentes leur permettant de répondre à leurs questions cliniques concernant le traitement, diagnostic et pronostic des pathologies rencontrées (Evidence-Based Medicine). Plusieurs enjeux naissent à cette interface entre la production du savoir et son utilisation dans la pratique clinique.

Développement

Un premier enjeu important est celui de la recherche de littérature et de l’accès aux données pertinentes, dans un contexte où le savoir médical est très rapide expansion : 2000 à 4000 nouveaux articles publiés chaque jour dans la base de donnée Medline, qui comprend déjà plus de 20 millions de références indexées. Plusieurs outils et stratégies de recherche de littératures ont été proposés, mais leurs performances sont peu connues.

• PROJET N°1: PERFORMANCE OF RAPID LITERATURE SEARCH STRATEGIES IN CLINICAL PRACTICE. 
  Thomas Agoritsas et al. – Projet en cours 
  L’objectif de cette étude est d’explorer et comparer la performance de plusieurs stratégies de recherche de littérature, applicables en pratique clinique, dans l’identification d’articles pertinents pour une question clinique donnée.

Un second enjeu est la compréhension et appréciation critique des méthodes de recherche employées. Par exemple, plusieurs études ont montré qu’il n’est pas réaliste d’attendre des cliniciens qu’ils comprennent l’entièreté des concepts statistiques et méthodologiques déployés dans la littérature originale. Plusieurs journaux d’Evidence-Based Medicine ont tenté de palier ce problème en publiant une sélection d’articles résumés, simplifiés et commentés par des experts (second-order peer review littérature, tels que Journal Watch ou Evidence Update).

• PROJET N°2: WHAT METHODOLOGICAL CONCEPTS DO PEDIATRICIANS NEED TO KNOW IN ORDER TO UNDERSTAND SECOND-ORDER PEER REVIEW LITERATURE? 
  Arnaud Merglen, Thomas Agoritsas et al. – Projet en cours 
  En collaboration avec la Plateforme de Recherche du Département de Pédiatrie des HUG, nous nous sommes donnés l’objectif d’identifier et analyser les concepts épidémiologiques et statistiques minimaux que les cliniciens doivent connaître pour aborder la littérature médicale secondaire.

Enfin, un dernier enjeu est l’utilisation effective des données publiées dans leur pratique clinique (knowledge translation). Cette utilisation nécessite souvent des connaissances méthodologiques précises. L’identification des difficultés et barrières dans ce domaine est essentielle afin d’espérer améliorer l’utilisation correctes des données publiées.

• PROJET N°3 : DOES PREVALENCE MATTER TO PHYSICIANS IN ESTIMATING POST-TEST PROBABILITY OF DISEASE? A RANDOMIZED TRIAL. 
  Agoritsas T, Courvoisier DS, Combescure C, Deom M, Perneger TV. 
  Published in : J Gen Intern Med 2010. 
  Dans cette étude en particulier, nous avons pu montrer que la plupart des médecins ne tiennent pas compte de la prévalence d’une pathologie (probabilité pré-test) lorsqu’ils interprètent les résultats d’un test diagnostique (probabilité post-test). Cela peut conduire à un excès de tests diagnostiques inutiles et anxiogènes, voire parfois à des erreurs diagnostiques.

< RETOUR

• Articles 2014
• Articles 2013
• Articles 2012
• Articles 2011
• Articles 2010
• Articles 2009
• Articles 2008
• Articles 2007

• Editos 2009
• Editos 2008
• Editos 2007

Articles

2014

• Perneger TV, Cullati S, Rudaz S, Agoritsas T, Schmidt RE, Combescure C, Courvoisier DS. Effect of numbering of return envelopes on participation, explicit refusals, and bias: experiment and meta-analysis. BMC Med Res Methodol. 2014 Jan 15;14:6. doi: 10.1186/1471-2288-14-6. PubMed PMID: 24428941; PubMed Central PMCID: PMC3898011.
• Perneger TV, Courvoisier DS, Hudelson PM, Gayet-Ageron A. Sample size for pre-tests of questionnaires. Qual Life Res (epub)
• Combescure C, Perneger T, Weber DC, Daurès J-P, Foucher Y. Prognostic ROC curves: a method for representing the overall discriminative capacity of binary markers with right-censored time-to-event endpoints. Epidemiology 2014;25:103-9 (abstract)
• Courvoisier DS, Cullati S, Ouichi R, Schmidt RE, Haller G, Chopard P, Agoritsas T, Perneger TV. Validation of a 15-item care-related regret coping scale (RCS-HCP) for healthcare professionals. J Occup Health 2014 (epub)
• Gayet-Ageron A, Sednaoui P, Lautenschlager S, Ferry T, Toutous-Trellu L, Cavassini M, Yassir F, Martinez de Tejada B, Emonet S, Combescure C, Schrenzel J, Perneger T. Multicentre European study on Treponema pallidum Polymerase Chain Reaction in sexually-transmitted ulcerative diseases. Emerg Infect Dis 2014 (in press)
• Perneger TV, Staines A, Kun dig F. Internal consistency, factor structure, and construct validity of the French version of the Hospital Survey on Patient Safety Culture. BMJ Qual Saf 2014;23:389-97 (abstract)
• Jannot AS, Perneger T. What should be the basis for compulsory and optional health insurance premiums: opinions of Swiss doctors. Swiss Med Wkly 2014;144:w13918 (abstract)
• Escher M, Perrier A, Rudaz S, Dayer P, Perneger TV. Doctors’ decisions when faced with contradictory patient advance directives and a health care proxy opinion: a randomized vignette-based study. J Pain Symptom Manage 2014 (in press)
• Parvex P, Combescure C, Rodriguez M, Birraux J, Girardin E. Evaluation and predictive factors of renal function progression using cystatin C and creatinine in neonates born with CAKUT. Clin Nephrol. 2014 May;81(5):338-44. doi: 10.5414/CN108149. PubMed PMID: 24691013. (abstract)
• Terzic A, Combescure C, Scolozzi P. Accuracy of computational soft tissue predictions in orthognathic surgery from three-dimensional photographs 6 months after completion of surgery: a preliminary study of 13 patients. Aesthetic Plast Surg. 2014 Feb;38(1):184-91. doi: 10.1007/s00266-013-0248-4. Epub 2013 Dec 13. PubMed PMID: 24337148. (abstract)
• Escher M, Perneger TV, Rudaz S, Dayer P, Perrier A. Impact of advance directives and a health care proxy on doctors' decisions: a randomized trial. J Pain Symptom Manag 2014;47:1-11 (abstract)
• Meyer Ganz O, Tobalem M, L am GT, Modarressi A, Elias B, Perneger T, Pittet BRisks and benefits of using an absorbable mesh in one-stage immediate breast reconstruction: a comparative study. Plast Reconstr Surg 2014 (in press)
• Lübbeke A, Zimmermann-Sloutskis D, Stern R, Roussos C, Bonvin A, Perneger T, Peter R, Hoffmeyer P. Physical activity before and after primary total hip arthroplasty: a registry-based study. Arthritis Care Res 2014;66:276-84 (abstract)
• Iranmanesh P, Vazquez O, Terraz S, Majno P, Spahr L, Poncet A, et al. Accurate computed tomography-based portal pressure assessment in patients with hepatocellular carcinoma. JHepatol 2013; pii: S0168-8278(13)00883-0.
• Le Gal F, Lebon S, Ramelli GP, Datta AN, Mercati D, Maier O, Combescure C, Rodriguez MI, Seeck M, Roulet E, Korff CM. When is a child with status epilepticus likely to have Dravet syndrome? Epilepsy Res. 2014 May;108(4):740-7. doi: 10.1016/j.eplepsyres.2014.02.019. Epub 2014 Mar 12. PubMed PMID: 24679980.
• Fonzo-Christe C, Guignard B, Zaugg C, Coehlo A, Posfay-Barbe KM, Gervaix A, Desmeules J, Rollason V, Combescure C, Corbelli R, Rimensberger P, Pfister R, Bonnabry P. Impact of clinical decision support guidelines on therapeutic drug monitoring of gentamicin in newborns. Ther Drug Monit. 2014 Oct;36(5):656-62. doi: 10.1097/FTD.0000000000000071. PubMed PMID: 24690586.
• Combescure C, Foucher Y, Jackson D. Meta-analysis of single-arm survival studies: a distribution-free approach for estimating summary survival curves with random effects. Stat Med. 2014 Jul 10;33(15):2521-37. doi: 10.1002/sim.6111. Epub 2014 Feb 13. PubMed PMID: 24532219.
• Courvoisier DS. Cellphone well-being. In: Michalos AC, editor. Encyclopedia of quality of life and well-being research. Dordrecht, Netherlands: Springer; 2014. p. 633-4.
• Burri H, Combescure C. Management of recalled implantable cardioverter-defibrillator leads at generator replacement: a decision analysis model for Fidelis leads. Europace. 2014 Aug;16(8):1210-7. doi: 10.1093/europace/eut425. Epub 2014 Jan 26. PubMed PMID: 24469434.
• Toso C, Majno P, Berney T, Morel P, Mentha G, Combescure C. Validation of a dropout assessment model of candidates with/without hepatocellular carcinoma on a common liver transplant waiting list. Transpl Int. 2014Jul;27(7):686-95. doi: 10.1111/tri.12323. Epub 2014 Apr 25. PubMed PMID: 24649861.
• Dantan E, Combescure C, Lorent M, Ashton-Chess J, Daguin P, Classe JM, Giral M, Foucher Y. An original approach was used to better evaluate the capacity of a prognostic marker using published survival curves. J Clin Epidemiol. 2014 Apr;67(4):441-8. doi: 10.1016/j.jclinepi.2013.10.022. PubMed PMID: 24581297.
• Weber DC, Hurkmans CW, Melidis C, Budach W, Langendijk JH, Peters LJ, Grégoire V, Maingon P, Combescure C. Outcome impact and cost-effectiveness of quality assurance for radiotherapy planned for the EORTC 22071-24071 prospective study for head and neck cancer. Radiotherapy and Oncology. 2014 Jun;111(3):393-9. doi: 10.1016/j.radonc.2014.04.015. Epub 2014 May 23. PubMed PMID: 24861631.
• Girardin FR, Poncet A, Blondon M, Rollason V, Vernaz N, Chalandon Y, Dayer P, Combescure C. Cost-effectiveness of monitoring white blood cell count in psychotic adults on clozapine. The Lancet Psychiatry.doi: 10.1016/S2215-0366(14)70245-7
• P. Fontana, A. Poncet, E. Lindhoff-Last, P. de Moerloose, K. M. Devreese. Refinement of the cutoff values of the HemosIL AcuStar assay for the detection of anticardiolipin and anti–beta2 glycoprotein-1 antibodies. JTH-Journal of Thrombosis and Haemostasis (2014). DOI: 10.1111/jth.12732
• Cullati S, Courvoisier DS, Burton-Jeangros C. Mental health trajectories and their embeddedness in work and family circumstances: A latent state-trait approach to life-course trajectories. Sociology of Health and Illness in press.
• Kocum L, Courvoisier DS. The Social Identity of Working Women: Queen Bee Phenomenon or Collective Mobility Strategy? In: Fisher M, editor. Handbook of Women and Competitionin press.
• Imholz B, Combescure C, Scolozzi P. Is age of the patient an independent predictor influencing the management of cranio-maxillo-facial trauma? A retrospective study of 308 patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jun;117(6):690-6. doi: 10.1016/j.oooo.2014.03.010. Epub 2014 Mar 24. PubMed PMID: 24842446.
• Ribi C, Trendelenburg M, Gayet-Ageron A, Cohen C, Dayer E, Eisenberger U, Hauser T, Hunziker T, Leimgruber A, Lindner G, Koenig K, Otto P, Spertini F, Stoll T, Von Kempis J, Chizzolini C; Swiss Systemic Lupus Erythematosus Cohort Study Group.The Swiss Systemic lupus erythematosus Cohort Study (SSCS) - cross-sectional analysis of clinical characteristics and treatments across different medical disciplines in Switzerland. Swiss Med Wkly. 2014 Aug 7;144:w13990. doi: 10.4414/smw.2014.13990. eCollection 2014.
• Stewardson AJ, Iten A, Camus V, Gayet-Ageron A, Caulfield D, Lacey G, Pittet D. Efficacy of a new educational tool to improve Handrubbing technique amongst healthcare workers: a controlled, before-after study. PLoS One. 2014 Sep 2;9(9):e105866. doi: 10.1371/journal.pone.0105866. eCollection 2014.
• Robert-Ebadi H, Bertoletti L, Combescure C, Le Gal G, Bounameaux H, Righini M. Effects of impaired renal function on levels and performance of D-dimer in patients with suspected pulmonary embolism. Thrombosis and Haemostasis. 2014 Sep 2;112(3):614-20. doi: 10.1160/TH13-12-1024. Epub 2014 Jun 5. PubMed PMID: 24898973.
• Gex G, Pralong JA, Combescure C, Seijo L, Rochat T, Soccal PM. Diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules: a systematic review and meta-analysis. Respiration. 2014;87(2):165-76. doi: 10.1159/000355710. Epub 2014 Jan 3. PubMed PMID: 24401166.
• Cullati S, Rousseaux E, Courvoisier DS, Gabadinho A, Burton-Jeangros C. Factors of change and cumulative factors in self-rated health trajectories: a systematic review. Advances in Life Course Research 2014; 19: 14-27
• Haller C, Etter JF, Courvoisier DS. Trajectories in cigarette dependence as a function of anxiety: A multilevel analysis. Drug Alcohol Depend 2014.
• Genevay S, Marty M, Rozenberg S, Courvoisier DS, Cedraschi C, for the Spine Group of the French Society of Rheumatology. Core Outcome Measure Index: full validation process of the French version. Eur Spine J in press.
• Hudelson P, Domnicé-Dao M, Perneger TV, Durieux S. A “Migrant Friendly Hospital” initive in Geneva, Switzerland: evaluation of the effects on staff knowledge and practices. PLoS One 2014;9:e106758.
• Calinescu, A M; Wildhaber, B E; Poncet, A; et al. Outcomes of combined liver-kidney transplantation in children: analysis of the scientific registry of transplant recipients. American journal of transplantation (2014). DOI: 10.1111/ajt.12935
• Leuchter, Russia Ha-Vinh; Gui, Laura; Poncet, Antoine; et al. Association Between Early Administration of High-Dose Erythropoietin in Preterm Infants and Brain MRI Abnormality at Term-Equivalent Age.JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014). DOI: 10.1001/jama.2014.9645
• Roberta De Luca, Pierre Fontana, Antoine Poncet, Philippe de Moerloose, Riccardo E. Pfister. Evaluation of the GEM®PCL Plus point-of-care device for neonatal coagulation assessment: An observational study on cord blood. Thrombosis Research (2014). DOI: 10.1016/j.thromres.2014.05.024
• Zingg W, Cartier V, Inan C, Touveneau S, Theriault M, Gayet-Ageron A, Clergue F, Pittet D, Walder B. Hospital-wide multidisciplinary, multimodal intervention programme to reduce central venous catheter-associated bloodstream infection. PLoS One. 2014 Apr 8;9(4):e93898. doi: 10.1371/journal.pone.0093898. eCollection 2014.
• Longtin Y, Schneider A, Tschopp C, Renzi G, Gayet-Ageron A, Schrenzel J, Pittet D. Contamination of stethoscopes and physicians' hands after a physical examination. Mayo Clin Proc. 2014 Mar;89(3):291-9. doi: 10.1016/j.mayocp.2013.11.016.
• Jung M, Volonté F, Buchs NC, Gayet-Ageron A, Pugin F, Gervaz P, Ris F, Morel P Perirenal fat surface area as a risk factor for morbidity after elective colorectal surgery. Dis Colon Rectum. 2014 Feb;57(2):201-9. doi: 10.1097/DCR.0000000000000029.
• Cunningham G, Seghrouchni K, Ruffieux E, Vaudaux P, Gayet-Ageron A, Cherkaoui A, Godinho E, Lew D, Hoffmeyer P, Uçkay I. Gram and acridine orange staining for diagnosis of septic arthritis in different patient populations. Int Orthop. 2014 Jun;38(6):1283-90. doi: 10.1007/s00264-014-2284-3. Epub 2014 Feb 5.
• Siegenthaler N, Giraud R, Saxer T, Courvoisier DS, Romand J-A, Brochard L, et al. Hemodynamic monitoring in Swiss intensive care units: results from a web based survey. BioMed Res Int 2014.
• Almaghlouth A, Cionca N, Cancela J, Décaillet F, Courvoisier DS, Giannopoulou C, et al. Effect of periodontal treatment on peak serum levels of inflammatory markers. Clinical Oral Investigations 2014: 1-9. 
• Garin N, Genné D, Carballo S, Chuard C, Eich G, Hugli O, Lamy O, Nendaz M, Petignat PA, Perneger T, Rutschmann O, Seravalli L, Harbarth S, Perrier A. b-Lactam monotherapy versus b-lactam-macrolide combinbation treatment in moderately severe community-acquired pneumonia : a randomized non-inferiority trial. JAMA Intern Med 2014 174 :1894-1901 
• Dekkers OM, Cevallos M, Bührer J, Poncet A, Ackermann-Rau S, Perneger TV, Egger M. Comparison of non-inferiority margins in protocols and publications showed incomplete and inconsistent reporting. J Clin Epidemiol (epub) 
• Arthur Varoquaux, Olivier Rager, Antoine Poncet, Bénédicte M. A. Delattre, Osman Ratib, Christoph D. Becker, Pavel Dulguerov, Nicolas Dulguerov, Habib Zaidi, Minerva Becker. Detection and quantification of focal uptake in head and neck tumours: F-18-FDG PET/MR versus PET/CT. Eur J Nucl Med Mol Imaging (2014) 41:462–475. DOI 10.1007/s00259-013-2580-y 
• Fleury, Vanessa; Cousin, Emilie; Czernecki, Virginie; Schmitt, Emmanuelle ; Lhommée, Eugénie; Poncet, Antoine; et al. Dopaminergic modulation of emotional conflict in Parkinson's disease. FRONTIERS IN AGING NEUROSCIENCE (2014). DOI: 10.3389/fnagi.2014.0016

2013

• Y. Longtin, A. Schneider, C. Tschopp, G. Renzi, A. Gayet-Ageron, Jacques Schrenzel, D. Pittet. Contamination of stethoscopes and physicians’ hands following a physical examination. Mayo Clinic Proceedings, 2013, in press
• A Matthey, C Cedraschi, V Piguet, M Besson, J Chabert, Y Daali, D Courvoisier, A Montagne, P Dayer, JA Desmeules. Dual Reuptake Inhibitor Milnacipran And Spinal Pain Pathways In Fibromyalgia Patients: A Randomized Double-Blind Placebo-Controlled Trial. Clinical Therapeutics. 2013/8
• AC Alba, T Agoritsas, M Jankowski, D Courvoisier, S Walter, GH Guyatt, HJ Ross. Risk Prediction Models for Mortality in Ambulatory Heart Failure Patients: A Systematic Review. The Journal of Heart and Lung Transplantation. 2013/4/30
• Alexandre Wullschleger, Viktoria Kapina, Nicolas Molnarfi, Delphine S Courvoisier, Jörg D Seebach, Marie-Laure Santiago-Raber, Denis F Hochstrasser, Patrice H Lalive. Cerebrospinal Fluid Interleukin-6 in Central Nervous System Inflammatory Diseases. PloS one 2013/8/27
• B. Allegranzi, A. Gayet-Ageron, N. Damani, L. Bengaly, ML. McLaws, ML. Moro, Z. Memish, O. Urroz, H. Richet, J. Storr, L. Donaldson, D. Pittet. Successful implementation of the World Health Organization multimodal hand hygiene improvement strategy across facilities worldwide: a quasi-experimental study. Lancet Infect Dis. 2013 Oct;13(10):843-51
• Balagué N, Combescure C, Huber O, Pittet-Cuénod B, Modarressi A. Plastic surgery improves long-term weight control after bariatric surgery. Plast Reconstr Surg. 2013 Oct;132(4):826-33. doi: 10.1097/PRS.0b013e31829fe531. PubMed PMID: 24076675.
• Baratti-Mayer D‡, A. Gayet-Ageron‡ (‡co-premiers auteurs), S. Hugonnet, P. François, B. Pittet-Cuenod, JE. Bornand, I. Bolivar, A. Gervaix, , D. Montandon, J. Schrenzel, A. Mombelli, D. Pittet, for the Geneva Study Group on Noma (GESNOMA). Risk factors for noma disease: results of a six-year, prospective, matched case-control study in Niger. Lancet Global Health. 2013;1(2):e87-96
• Barone-Rochette G, Machecourt J, Vanzetto G, Foote A, Quesada JL, Castelli C, Danchin N, Combescure C; EVASTENT Investigators. The favorable price evolution between bare metal stents and drug eluting stents increases the cost effectiveness of drug eluting stents. Int J Cardiol. 2013 Sep 30;168(2):1466-71. doi: 10.1016/j.ijcard.2012.12.054. Epub 2013 Jan 19. PubMed PMID: 23336951.
• Benkebil F, Combescure C, Anghel SI, Besson Duvanel C, Schäppi MG. Diagnostic accuracy of a new point-of-care screening assay for celiac disease. World J Gastroenterol. 2013 Aug 21;19(31):5111-7. doi: 10.3748/wjg.v19.i31.5111. PubMed PMID: 23964145; PubMed Central PMCID: PMC3746383.
• Christopher van Issum, Delphine S Courvoisier, Paolo Scolozzi. Posttraumatic orbital emphysema: incidence, topographic classification and possible pathophysiologic mechanisms. A retrospective study of 137 patients. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.Volume 115, Issue 6, June 2013, Pages 737–742
• Combescure C, Courvoisier DS, Haller G, Perneger TV. Meta-analysis of two-arm studies: modelling the intervention effect from survival probabilities. Stat Meth Med Res 2013
• Combescure C, Daures J, Foucher Y. A literature-based approach to evaluate the predictive capacity of a marker using time-dependent summary receiver operating characteristics. Statistical Methods in Medical Research.
• Combescure C, Perneger T, Weber DC, Daurès J-P, Foucher Y. Prognostic ROC curves: a method for representing the overall discriminative capacity of binary markers with right-censored time-to-event endpoints. Epidemiology 2014;25:103-9 PMID: 24240658.
• Courvoisier DS, Cullati S, Haller CS, Schmidt RE, Haller G, Agoritsas T, Perneger TV. Validation of a 10-item care-related regret intensity scale (RIS-10) for healthcare professionals. Med Care 2013;51:285-91
• Delphine Courvoisier, Arnaud Merglen, Thomas Agoritsas. Experiencing regrets in clinical practice. The Lancet, Volume 382, Issue 9904, Pages 1553 - 1554, 9 November 2013
• Delphine S Courvoisier, Olivier Renaud, Christian Geiser, Kerstin Paschke, Kevin Gaudy, Kirsten Jordan. Sex hormones and mental rotation: An intensive longitudinal investigationVolume 63, Issue 2, February 2013, Pages 345–351. Hormones and behavior.
• Dominique Monnin, Delphine Courvoisier, Stéphane Genevay, Danièle Kupper, Pascal Nguyen. Efficacité d’un programme de prévention du mal de dos pour les collaborateurs des institutions de médico-sociales de Genève. Kinésithérapie. 2013/2/28
• Duxbury B, Combescure C, Chizzolini C. Rituximab in systemic lupuserythematosus: an updated systematic review and meta-analysis. Lupus. 2013;22(14):1489-503. doi: 10.1177/0961203313509295. Epub 2013 Oct 17. PubMed PMID: 24135078
• Escher M, Perneger TV, Rudaz S, Dayer P, Perrier A. Impact of advance directives and of health care proxy on doctors' decisions: a randomized trial. J Pain Symptom Manag 2013 (in press)
• F. Montecucco, I. Bauer, V. Braunersreuther, S. Bruzzone, A. Akhmedov, TF. Lüscher, T. Speer, A. Poggi, E. Mannino, G. Pelli, K. Galan, M. Bertolotto, S. Lenglet, A. Garuti, C. Montessuit, R. Lerch, C. Pellieux, N. Vuilleumier, F. Dallegri, J. Mage, C. Sebastian, R. Mostoslavsky, A. Gayet-Ageron, F. Patrone, F. Mach, A. Nencioni. Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction. Antioxid Redox Signal. 2013; 18(6):630-41
• Fontana P, Cattaneo M, Combescure C, Reny JL. Tailored Thienopyridine therapy: no urgency for CYP2C19 genotyping. J Am Heart Assoc. 2013 Mar 27;2(2):e000131. doi: 10.1161/JAHA.112.000131. PubMed PMID: 23537811; PubMed Central PMCID: PMC3647256.
• Gayet-Ageron A, S. Lautenschlager, B. Ninet, TV. Perneger, C. Combescure. Sensitivity, specificity and likelihood ratios of PCR in the diagnosis of syphilis: a systematic review and meta-analysis. Sex Transm Infect. 2013 May; 89(3):251-6
• Gervaz P, Platon A., Buchs N, Rocher T, Perneger T, Poletti PA. CT-scan based modeling of anastomotic leak risk after colorectal surgery. Colorectal Dis 2013;15:1295-300
• Gschwind L, Rollason V, Boehlen F, Rebsamen M, Combescure C, Grünenwald M, Matthey A, Bonnabry P, Dayer P, Desmeules JA. Impact of CYP2C9 polymorphisms on the vulnerability to pharmacokinetic drug-drug interactions during acenocoumarol treatment. Pharmacogenomics. 2013 May;14(7):745-53. doi: 10.2217/pgs.13.55. PubMed PMID: 23651023.
• I. Uckay, H. Sax, A. Gayet-Ageron, C. Ruef, K. Mühlemann, N. Troillet, C. Petitgnat, E. Bernasconi, C. Balmelli, A. Widmer, K. Boubaker, D. Pittet ; Swiss-NOSO network. High proportion of healthcare-associated urinary tract infection in the absence of prior exposure to urinary catheter: a cross-sectional study. Antimicrob Resist Infect Control. 2013;7(2):5
• Jannot AS, Agoritsas T, Gayet-Ageron A, Perneger TV. Citation bias favoring statistically significant results is present in medical research. J Clin Epidemiol 2013;66:296-301
• Laura Merlini, Antoine Poncet. DTI measurements of non-decussating fibers in Defective Axon Guidance Disorders (Horizontal Gaze Palsy and Progressive Scoliosis and Joubert Syndrome). Journal of Pediatric Neuroradiology2 (2013) 131–139. DOI 10.3233/PNR-13054
• Laure-Anne Prisse, Delphine S Courvoisier, Paolo Scolozzi. Did the Hand Drawn Cephalometric Tracing Technique for Orthognathic Surgery Planning say its Last Word? Objective and Subjective Evaluation. The Journal of craniofacial surgery[2013, 24(4):e320-5]
• Lavigne JP, Cuzon G, Combescure C, Bourg G, Sotto A, Nordmann P. Virulence of Klebsiella pneumoniae isolates harboring bla KPC-2 carbapenemase gene in a Caenorhabditis elegans model. PLoS One. 2013 Jul 2;8(7):e67847. doi: 10.1371/journal.pone.0067847. Print 2013. PubMed PMID: 23844109; PubMed Central PMCID: PMC3699468.
• Lübbeke A, Zimmermann-Sloutskis D, Stern R, Roussos C, Bonvin A, Perneger T, Peter R, Hoffmeyer P. Physical activity before and after primary total hip arthroplasty: a registry-based study. Arthritis Care Res 2013 (epub)
• Martinet M, Borradori Tolsa C, Rossi Jelidi M, Bullinger A, Perneger T, Pfister RE. Elaboration et validation de contenu d’une grille d’observation du comportement sensori-moteur du nouveau-né à l’usage du personnel soignant. Arch Pediatr 2013;20:137-45.
• Martinez de Tejada B, Jastrow N, Poncet A, Le Scouezec I, Irion O, Kayser B. Perceived and measured physical activity and mental stress levels in obstetricians. Eur J Obstet Gynecol Reprod Biol. 2013 Aug 16. pii: S0301-2115(13)00410-7. doi: 10.1016/j.ejogrb.2013.08.020
• Michel Gonzalez, Antoine Poncet, Christophe Combescure, John Robert, Hans Beat Ris & Pascal Gervaz. Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Annals of Surgical Oncology (2013) 20:572-579; DOI: 10.1245/s10434-012-2726-3
• Paolo Scolozzi, Armen Momjian, DS Courvoisier, Stavros Kiliaridis. Evaluation of condylar morphology following orthognathic surgery on digital panoramic radiographs. Could methodology influence the range of “normality” in condylar changes? Dentomaxillofacial Radiology. 2013/4/26
• Pasquale F. Innominato, Sylvie Giacchetti, Thierry Moreau, Georg A. Bjarnason, Rune Smaaland, Christian Focan, Carlo Garufi, Stefano Iacobelli, Marco Tampellini, Salvatore Tumolo, Carlos Carvalho, Abdoulaye Karaboue, Antoine Poncet, David Spiegel, and Francis Levi. Fatigue and Weight Loss Predict Survival on Circadian Chemotherapy for Metastatic Colorectal Cancer. Cancer 2013. DOI: 10.1002/cncr.28072
• Perneger TV, Gayet-Ageron A, Courvoisier DS, Agoritsas T, Cullati S. Self-rated health: analysis of distances and transitions between response options. Qual Life Res 2013;22:2761-8
• Perneger TV, Staines A, Kundig F. Internal consistency, factor structure, and construct validity of the French version of the Hospital Survey on Patient Safety Culture. BMJ Qual Saf 2013 (epub)
• Poletti PA, Platon A, De Seigneux S, Dupuis-Lozeron E, Sarasin F, Becker CD, Perneger T, Saudan P, Martin PY. N-acetylcysteine does not prevent contrast nephropathy in patients with renal impairment undergoing emergency CT: a randomized study. BMC Nephrol 2013;13:119
• Rizk B, Platon A, Tasu JP, Becker CD, Mendes Pereira V, Perneger T, Shanmuganathan K, Lövblad KO, Poletti PA. The role of unenhanced CT alone for the management of headache in an emergency department: a feasibility study. J Neuroradiol 2013;40:235-41
• Rohner GB, Meier S, Bel M, Combescure C, Othenin-Girard V, Swali RA, de Tejada BM, Siegrist CA. Influenza Vaccination Given at Least 2 Weeks before Delivery to Pregnant Women Facilitates Transmission of Seroprotective Influenza-Specific Antibodies to the Newborn. Pediatr Infect Dis J. 2013 Sep 20. [Epub ahead of print] PubMed PMID: 24061270.
• Stewardson AJ, Allegranzi B, Perneger T, Attar H, Pittet D. Testing the WHO Hand Hygiene Self-Assessment Framework for usability and reliability. J Hosp Infect 2013;83:30-5
• Sylviane Hanquinet, Anne‐Laure Rougemont, Delphine Courvoisier, Laura Rubbia-Brandt, Valérie Mclin, Michela Tempia, Mehrak Anooshiravani. Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children. Pediatric radiology. 2013/3/1
• Vazquez L, Nizamaldin Y, Combescure C, Nedir R, Bischof M, Dohan Ehrenfest DM, Carrel JP, Belser UC. Accuracy of vertical height measurements on direct digital panoramic radiographs using posterior mandibular implants and metal balls as reference objects. Dentomaxillofac Radiol. 2013;42(2):20110429. doi: 10.1259/dmfr.20110429. PubMed PMID: 23360688; PubMed Central PMCID: PMC3699017.
• Vernaz N, Haller G, Girardin F, Huttner B, Combescure C, Dayer P, Muscionico D, Salomon JL, Bonnabry P. Patented drug extension strategies on healthcare spending: a cost-evaluation analysis. PLoS Med. 2013 Jun;10(6):e1001460. doi: 10.1371/journal.pmed.1001460. Epub 2013 Jun 4. PubMed PMID: 23750120; PubMed Central PMCID: PMC3672218.
• Vuilleumier N, Montecucco F, Spinella G, Pagano S, Bertolotto M, Pane B, Pende A, Galan K, Roux-Lombard P, Combescure C, Dallegri F, Mach F, Palombo D. Serum levels of anti-apolipoprotein A-1 auto-antibodies and myeloperoxidase as predictors of major adverse cardiovascular events after carotid endarterectomy. Thromb Haemost. 2013 Apr;109(4):706-15. doi: 10.1160/TH12-10-0714. Epub 2013 Jan PubMed PMID: 23364307.

2012

• Agoritsas T, Merglen A, Courvoisier DS, Combescure C, Garin N, Perrier A, Perneger TV. Sensitivity and predictive value of 15 PubMed search strategies to answer clinical questions rated against full systematic reviews. J Med Internet Res. 2012 Jun 12;14(3):e85. PubMed PMID: 22693047; PubMed Central PMCID: PMC3414859. (abstract)
• Andres A, Gerstel E, Combescure C, Asthana S, Merani S, Majno P, Berney T, Morel P, Kneteman N, Mentha G, Toso C. A score predicting survival after liver retransplantation for hepatitis C virus cirrhosis. Transplantation. 2012 Apr 15;93(7):717-22. PubMed PMID: 22267157. (abtract)
• Blanchard-Rohner G, Meier S, Ryser J, Schaller D, Combescure C, Yudin MH, Burton-Jeangros C, de Tejada BM, Siegrist CA. Acceptability of maternal immunization against influenza: the critical role of obstetricians. J Matern Fetal Neonatal Med. 2012 Sep;25(9):1800-9. Epub 2012 Mar 16. PubMed PMID: 22339083. (abstract)
• Cachat F, Combescure C, Chehade H, Zeier G, Mosig D, Meyrat B, Frey P, Girardin E. Microalbuminuria and hyperfiltration in subjects with nephro-urological disorders. Nephrol Dial Transplant. 2012 Dec 6. [Epub ahead of print] PubMed PMID: 23223226. (abstract)
• Calmy A, Bel M, Nguyen A, Combescure C, Delhumeau C, Meier S, Yerly S, Kaiser L, Hirschel B, Siegrist CA; H1N1 Study Group. Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients. HIV Med. 2012 Apr;13(4):207-18. doi: 10.1111/j.1468-1293.2011.00961.x. Epub 2011 Nov 7. PubMed PMID: 22093373. (abstract)
• Ceroni D, Dubois-Ferrière V, Anderson R, Combescure C, Lamah L, Cherkaoui A, Schrenzel J. Small risk of osteoarticular infections in children with asymptomatic oropharyngeal carriage of kingella kingae. Pediatr Infect Dis J. 2012 Sep;31(9):983-5. PubMed PMID: 22572754. (abstract)
• Contal O, Vignaux L, Combescure C, Pepin JL, Jolliet P, Janssens JP. Monitoring of noninvasive ventilation by built-in software of home bilevel ventilators: a bench study. Chest. 2012 Feb;141(2):469-76. doi: 10.1378/chest.11-0485. Epub 2011 Jul 21. PubMed PMID: 21778253. (abstract)
• Combescure C, Courvoisier D, Haller G, Perneger T. Meta-analysis of two-arm studies: Modeling the intervention effect from survival probabilities. Stat Methods Med Res. 2012 Dec 24. [Epub ahead of print] PubMed PMID: 23267027. (abstract)
• Combescure C, Daures J, Foucher Y. A literature-based approach to evaluate the predictive capacity of a marker using time-dependent summary receiver operating characteristics. Stat Methods Med Res. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 23117409. (abstract)
• Courvoisier DS, Agoritsas T, Glauser J, Michaud K, Wolfe F, Cantoni E, Perneger TV, Finckh A. Pain is the most important predictor of psychosocial health in patients with rheumatoid arthritis. Arthrit Care Res 2012;64:190-6. PMID: 21972106 (abstract)
• Della Torre R, Combescure C, Cortes B, Marazza G, Beltraminelli H, Naldi L, Borradori L. Clinical presentations and diagnostic delay in bullous pemphigoid: a prospective natiowide cohort. Br J Dermatol. 2012 Jun 18. doi:10.1111/j.1365-133.2012.11108.x. PubMed PMID: 22709136. (abstract)
• Dadoun S, Zeboulon-Ktorza N, Combescure C, Elhai M, Rozenberg S, Gossec L, Fautrel B. Mortality in rheumatoid arthritis over the last fifty years: Systematic review and meta-analysis. Joint Bone Spine. 2012 Mar 27. PubMed PMID: 22459416 (abtract)
• Gayet-Ageron A, Lautenschlager S, Ninet-Bescher B, Perneger T, Combescure C. Sensitivity, specificity, and likelihood ratios of polymerase chain reaction in the diagnosis of syphilis: a systematic review and meta-analysis. Sex Trans Dis 2012. PMID:23024223. (abstract)
• Gervaz P, Bandiera-Clerc C, Buchs N, Eisenring MC, Perneger T, Troillet N, Harbarth S. Scoring system to predict the risk of surgical-site infection after colorectal resection. Br J Surg 2012;99:589-95.PMID: 22231649. (abstact)
• Gex G, Gerstel E, Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Rutschmann OT, Perneger T, Perrier A. Is atrial fibrillation associated with pulmonary embolism? J Thromb Haemost 2012;10:347-51. PMID: 22212132. (abstract)
• Gonzalez M, Robert JH, Halkic N, Mentha G, Roth A, Perneger T, Ris HB, Gervaz P. Survival after lung metastasectomy in colorectal cancer patients with previously resected liver metastases. World J Surg 2012;36:386-91. PMID: 22167262. (abstract)
• Gonzalez M, Poncet A, Combescure C, Robert J, Ris HB, Gervaz P. Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Ann Surg Oncol. 2012 Oct 28. [Epub ahead of print] PubMed PMID: 23104709. (abstract)
• Gumy-Pause F, Pardo B, Khoshbeen-Boudal M, Ansari M, Gayet-Ageron A, Sappino AP, Attiyeh EF, Ozsahin H. GSTP1 hypermethylation is associated with reduced protein expression, aggressive disease and prognosis in neuroblastoma. Genes Chromosomes Cancer. 2011 Nov 1. doi: 10.1002/gcc.20941. PMID: 22045684. (abstract)
• Hottinger AF, George AC, Bel M, Favet L, Combescure C, Meier S, Grillet S, Posfay-Barbe K, Kaiser L, Siegrist CA, Dietrich PY; H1N1 Study Group. A prospective study of the factors shaping antibody responses to the AS03-adjuvanted influenza A/H1N1 vaccine in cancer outpatients. Oncologist. 2012;17(3):436-45. Epub 2012 Feb 21. PubMed PMID: 22357731; PubMed Central PMCID: PMC3316930. (abtract)
• Hudelson P, Perneger T, Kolly V, Junod Perron N. Self-assessed competency at working with a medical interpreter is not associated with knowledge of good practice. PloS One 2012;7:e38973. PMID: 22715421 (abstract)
• Kayser B, Dumont L, Lysakowski C, Combescure C, Haller G, Tramèr MR. Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and Meta-analysis. High Alt Med Biol. 2012 Jun;13(2):82-92. (abstract)
• Kern I, Xu R, Julien S, Suter DM, Preynat-Seauve O, Baquié M, Poncet A, Combescure C, Stoppini L, van Thriel C, Krause KH. Embryonic stem cell-based screen for small molecules: cluster analysis reveals four response patterns in developing neural cells. Curr Med Chem. 2012 Dec 10. [Epub ahead of print] PubMed PMID: 23231350. (abstract)
• Lavigne JP, Vergunst AC, Goret L, Sotto A, Combescure C, Blanco J, O'Callaghan D, Nicolas-Chanoine MH. Virulence potential and genomic mapping of the worldwide clone Escherichia coli ST131. PLoS One. 2012;7(3):e34294. Epub 2012 Mar 23. PubMed PMID: 22457832; PubMed Central PMCID: PMC3311635. (abstract)
• Longtin Y, Farquet N, Gayet-Ageron A, Sax H, Pittet D. Caregivers' Perceptions of Patients as Reminders to Improve Hand Hygiene. Arch Intern Med. 2012 Sep 3:1-2. (article)
• Marti C, Garin N, Grosgurin O, Poncet A, Combescure C, Carballo S, Perrier A. Prediction of severe community acquired pneumonia: a systematic review and meta-analysis. Critical Care 2012, 16 :R141. (abstract)
• Martinez de Tejada B, Gayet-Ageron A, Combescure C, Irion O, Baehni P. Association between early preterm birth and periodontitis according to USA and European consensus definitions. J Matern Fetal Neonatal Med. 2012 May 29. (abstract)
• Martinez de Tejada B, Gayet-Ageron A, Combescure C, Irion O, Baehni P. Association between early preterm birth and periodontitis according to USA and European consensus definitions. J Matern Fetal Neonatal Med. 2012 May 29.PubMed PMID: 22548257. (abstract)
• Mastelic B, Kamath AT, Fontannaz P, Tougne C, Rochat AF, Belnoue E, Combescure C, Auderset F, Lambert PH, Tacchini-Cottier F, Siegrist CA. Environmental and T cell-intrinsic factors limit the expansion of neonatal follicular T helper cells but may be circumvented by specific adjuvants. J Immunol. 2012 Dec 15;189(12):5764-72. doi: 10.4049/jimmunol.1201143. Epub 2012 Nov 16. PubMed PMID: 23162125. (abstract)
• Meier RP, Perneger TV, Stern R, Rizzoli R, Peter RE. Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med 2012;172:930-6. PMID: 22732749. (abstract)
• Nedir R, Nurdin N, Khoury P, Perneger T, El Hage M, Bernard JP, Bischof M. Osteotome sinus floor elevation with and without graft material in the atrophic maxilla. A 1-year prospective randomized controlled study. Clin Oral Implan Res 2012. PMID: 22925088. (abstract)
• Parvex P, Combescure C, Rodriguez M, Girardin E. Is Cystatin C a promising marker of renal function, at birth, in neonates prenatally diagnosed with congenital kidney anomalies? Nephrol Dial Transplant. 2012 Sep;27(9):3477-82. Epub 2012 Apr 3. PubMed PMID: 22474211. (abstract)
• Perneger TV, Deom M, Cullati S, Bovier PA. Growing discontent of Swiss doctors, 1998 to 2007. Eur J Public Health 2012 Aug;22(4):478-83. (abstract) 
• Poletti PA, Canel L, Becker CD, Wolff H, Elger B, Lock E, Sarasin F, Bonfanti MS, Dupuis-Lozeron E, Perneger T, Platon A. Screening for illegal intracorporeal containers (“body-packing”). Is abdominal radiography sufficiently accurate? A comparative study with low-dose CT. A comparative study with low-dose CT. Radiology 2012. PMID: 22952384. (abstract)
• Reny J-L, Berdague P, Poncet A, Barazar I, Nolli S, Fabbro-Peray P, Schved J-F, Bounameaux H, Mach F, de Moerloose P, Fontana P. Antiplatelet drug response status does not predict recurrent ischemic events in stable cardiovascular patients: results of the Antiplatelet Drug Resistances and Ischemic Events study. Circulation. 2012;125:3201–3210. (abstract)
• Reny JL, Combescure C, Daali Y, Fontana P; PON1 Meta-Analysis Group. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. J Thromb Haemost. 2012 Jul;10(7):1242-51. doi: 10.1111/j.1538-7836.2012.04756.x. PubMed PMID: 22520065. (abstract)
• Richards M, Lavigne Lissalde G, Combescure C, Batorova A, Dolan G, Fischer K, Klamroth R, Lambert T, Lopez-Fernandez M, Pérez R, Rocino A, Fijnvandraat K; European Haemophilia Treatment and Standardization Board. Neonatal bleeding in haemophilia: a European cohort study. Br J Haematol. 2012 Feb;156(3):374-82. doi: 10.1111/j.1365-2141.2011.08967.x. Epub 2011 Dec 7. PubMed PMID: 22146054. (abstract)
• Rochat I, Leis P, Perneger T, Bouchardy M, Oberli C, Sourial H, Friedli-Burri M, Barazzone Argiroffo C. Chest physiotherapy using passive expiratory techniques does not reduce bronchiolitis severity: a randomised controlled trial. Eur J Pediat 2012;171:457-62. (abstract)
• Schäppi MG, Meier S, Bel M, Siegrist CA, Posfay-Barbe KM; H1N1 Study Group. Protective antibody responses to influenza A/H1N1/09 vaccination in children with celiac disease. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):817-9. PubMed PMID: 22228003. (abstract)
• Siegrist CA, van Delden C, Bel M, Combescure C, Delhumeau C, Cavassini M, Clerc O, Meier S, Hadaya K, Soccal PM, Yerly S, Kaiser L, Hirschel B, Calmy A; H1N1 Study Group; Swiss HIV Cohort Study (SHCS). Higher Memory Responses in HIV-Infected and Kidney Transplanted Patients than in Healthy Subjects following Priming with the Pandemic Vaccine. PLoS One. 2012;7(7):e40428. Epub 2012 Jul 27. (abstract)
• Siegrist CA, Ambrosioni J, Bel M, Combescure C, Hadaya K, Martin PY, Soccal PM, Berney T, Noble S, Meier S, Posfay-Barbe K, Grillet S, Kaiser L, van Delden C; for the H1N1 study group. Responses of solid organ transplant recipients to the AS03-adjuvanted pandemic influenza vaccine. Antivir Ther. 2012;17(5):893-903. doi: 10.3851/IMP2103. Epub 2012 Apr 27. PubMed PMID: 22544169. (abstract)
• Stewardson AJ, Allegranzi B, Perneger T, Attar H, Pittet D. Testing the WHO Hand Hygiene Self-Assessment Framework for usability and reliability. J Hosp Infect 2012. PMID: 23149056. (abstract)
• Stoppa-Vaucher S, Dirlewanger MA, Meier CA, de Moerloose P, Reber G, Roux-Lombard P, Combescure C, Saudan S, Schwitzgebel VM. Inflammatory and prothrombotic States in obese children of European descent. Obesity (Silver Spring). 2012 Aug;20(8):1662-8. doi: 10.1038/oby.2012.85. Epub 2012 Apr 9. PubMed PMID: 22484367. (abstract)
• Toso C, Dupuis-Lozeron E, Majno P, Berney T, Kneteman NM, Perneger T, Morel P, Mentha G, Combescure C. A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list. Hepatology. 2012 Jul;56(1):149-56. doi: 10.1002/hep.25603. Epub 2012 Jun 18. PubMed PMID: 22271250. (abstract)
• Tonson la Tour A, Spadola L, Sayegh Y, Combescure C, Pfister R, Barazzone Argiroffo C, Rochat I. Chest CT in bronchopulmonary dysplasia: Clinical and radiological correlations. Pediatr Pulmonol. 2012 Nov 20. doi: 10.1002/ppul.22714. [Epub ahead of print] PubMed PMID: 23169612. (abstract)
• Weber DC, Tille JC, Combescure C, Egger JF, Laouiti M, Hammad K, Granger P, Rubbia-Brandt L, Miralbell R. The prognostic value of expression of HIF1α, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. Radiat Oncol. 2012 Apr 30;7:66. PubMed PMID: 22546016; PubMed Central PMCID: PMC3432017. (abstract)

2011

• Agoritsas T, Courvoisier DS, Combescure C, Deom M, Perneger TV. Post-test probability according to prevalence. J Gen Intern Med 2011;26:1091. PMID: 21751056 (letter)
• Agoritsas T, Courvoisier DS, Combescure C, Deom M, Perneger TV. Does prevalence matter to physicians in estimating post-test probability? A randomized trial. J Gen Intern Med 2011;26:373-8 (abstract)
• Agoritsas T, Perneger TV. Patient-reported conformity of informed consent procedures and participation in clinical research. QJM Int J Med 2011;104:151-9 (abstract)
• Agoritsas T, Deom M, Perneger TV. Study design attributes influenced patients’ willingness to participate in clinical research: a randomized vignette-based study. J Clin Epidemiol 2011;64:107-15 (abstract)
• Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, Pittet D. Burden of endemic healthcare-associated infection in developing countries: a systematic review and meta-analysis. Lancet. 2011 Jan 15;377(9761):228-41. (abstract)
• Biver E, Salliot C, Combescure C, Gossec L, Hardouin P, Legroux-Gerot I, Cortet B. Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011 Sep;96(9):2703-13. Epub 2011 Jul 21. (abstract)
• Bohanes P, Courvoisier DS, Perneger TV, Morel P, Huber O, Roth AD. Survival predictors in second-line chemotherapy for metastatic gastric cancer. Swiss Medical Weekly 2011;141:w13249. (article)
• Calmy A, Bel M, Nguyen A, Combescure C, Delhumeau C, Meier S, Yerly S, Kaiser L, Hirschel B, Siegrist CA; the H1N1 study group. Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients. HIV Med. 2011 Nov 7. [Epub ahead of print] (abstract)
• Ceroni D, Cherkaoui A, Combescure C, François P, Kaelin A, Schrenzel J. Differentiating Osteoarticular Infections Caused By Kingella Kingae From Those Due to Typical Pathogens in Young Children. Pediatr Infect Dis J. 2011 Apr 13. [Epub ahead of print]
• Combescure C, Courvoisier DS, Haller G, Perneger TV. Meta-analysis of binary outcomes from two-by-two tables when the length of follow-up varies and hazards are proportional. Statistical Methods in Medical Research. 2011, 20:531-40.
• Contal O, Vignaux L, Combescure C, Pepin JL, Jolliet P, Janssens JP. Monitoring of non-invasive ventilation by built-in software of home bi-level ventilators: a bench study. Chest. 2011 Jul 21. [Epub ahead of print] (abstract) 
• Cortés B, Marazza G, Naldi L, Combescure C, Borradori L; Autoimmune Bullous Disease Swiss Study Group. Mortality of bullous pemphigoid in Switzerland: a prospective study. Br J Dermatol. 2011 Aug;165(2):368-74. (abstract)
• Courvoisier DS, Agoritsas T, Perneger TV, Schmidt RE, Cullati S. Regrets associated with providing healthcare : qualitative study of experiences of hospital-based physicians and nurses. PloS One 2011;6:e23138 (article)
• Courvoisier DS, Combescure C, Agoritsas T, Haller G, Perneger TV. Performance of the logistic regression model : beyond the number of events per variable, the role of data structure. J Clin Epidemiol 2011 Sep;64(9):993-1000. (abstract)
• Courvoisier DS, Combescure C, Agoritsas T, Gayet-Ageron A, Perneger TV. Data structure remains relevant to determine EPV irrespective of type of bias. J Clin Epidemiol. (in press)
• Courvoisier DS, Agoritsas T, Glauser J, Michaud K, Wolfe F, Cantoni E, Perneger TV, Finckh A. Pain is the most important predictor of psychosocial health in patients with rheumatoid arthritis. Arthrit Care Res 2011. PMID: 21972106 (abstract)
• Courvoisier DS, Genevay S, Cedraschi C, Bessire N, Griesser-Delacrétaz AC, Monnin D, Perneger TV. Job strain, work characteristics, and back pain: study in a University hospital. Eur J Pain 2011;15:634-40 (abstract)
• Cullati S, Courvoisier DS, Charvet-Bérard AI, Perneger TV. Desire for autonomy in health care decisions: a general population survey. Patient Educ Couns. 2011 Apr;83(1):134-8. (abstract)
• Eichenberger AS, Haller G, Cheseaux N, Lechappe V, Garnerin P, Walder B. A Clinical Pathway in a Post-Anaesthesia Care Unit to Reduce Length of Stay, Mortality, and Unplanned Intensive Care Unit Admission. Eur. J. Anaesth 2011. PMID: 21885983 (abtract)
• El Amari EB, Combescure C, Yerly S, Calmy A, Kaiser L, Hasse B, Furrer H, Cavassini M, Vernazza P, Hirsch H, Bernasconi E, Hirschel B; for the Swiss HIV Cohort Study. Clinical relevance of cytomegalovirus viraemia(*,†). HIV Med. 2011 Aug;12(7):394-402. Epub 2011 Jan 19. PMID: 21251182 (abstract)
• Gabay C, Bel M, Combescure C, Ribi C, Meier S, Posfay-Barbe K, Grillet S, Seebach JD, Kaiser L, Wunderli W, Guerne PA, Siegrist CA; H1N1 Study Group. Impact of synthetic and biologic disease-modifying antirheumatic drugs on antibody responses to the AS03-adjuvanted pandemic influenza vaccine: A prospective, open-label, parallel-cohort, single-center study. Arthritis Rheum. 2011 Jun;63(6):1486-96. (abstract)
• Gariani K, Delabays A, Perneger TV, Agoritsas T. Use of brain natriuretic peptide to detect previously unknown left ventricular dysfunction in patients with acute exacerbation of chronic obstructive pulmonary disease. Swiss Med Wkly 2011;141:w13298 (article)
• Gayet-Ageron A, Agoritsas T, Schiesari L, Kolly V, Perneger TV. Barriers to participation in a patient satisfaction survey: who are we missing? PLoS One. 2011;6(10):e26852. Epub 2011 Oct 26. (article)
• Genevay S, Courvoisier DS, Cedraschi C, Griesser-Delacrétaz AC, Perneger TV, Monnin D. Work-related characteristics of back and neck pain among employees of a Swiss University hospital. Joint Bone Spine 2011. PMID: 21093343 (abstract)
• Gil-Wey B, Savoldelli GL, Kern C, Haller G. Risk factors associated with maternal satisfaction during childbirth: a retrospective cohort study. Can J Anaesth 2011 Jul 12 (abstract)
• Giraud R, Siegenthaler N, Gayet-Ageron A, Combescure C, Romand JA, Bendjelid K. ScvO2 As a Marker to Define Fluid Responsiveness. J Trauma. 2011 Apr;70(4):802-7. (abstract)
• Gossec L, Paternotte S, Maillefert JF, Combescure C, Conaghan PG, Davis AM, Gunther KP, Hawker G, Hochberg M, Katz JN, Kloppenburg M, Lim K, Lohmander LS, Mahomed NN, March L, Pavelka K, Punzi L, Roos EM, Sanchez-Riera L, Singh JA, Suarez-Almazor ME, Dougados M; OARSI-OMERACT Task Force "total articular replacement as outcome measure in OA". The role of pain and functional impairment in the decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1909 patients. Report of the OARSI-OMERACT Task Force on total joint replacement. Osteoarthritis Cartilage. 2011 Feb;19(2):147-54. (abstract)
• Gumy-Pause F, Pardo B, Khoshbeen-Boudal M, Ansari M, Gayet-Ageron A, Sappino AP, Attiyeh EF, Ozsahin H. GSTP1 hypermethylation is associated with reduced protein expression, aggressive disease and prognosis in neuroblastoma. Genes Chromosomes Cancer. 2011 Nov 1. doi: 10.1002/gcc.20941. (in press)
• Haller G, Agoritsas T, Luthy C, Piguet V, Griesser A-C, Perneger T. Collaborative quality improvement to manage pain in acute care hospitals. Pain Med 2011;12:138-47 (abstract)
• Haller G, Courvoisier DS, Anderson H, Myles PS. Clinical factors associated with the non-utilization of an anaesthesia incident reporting system. Br J Anesth. 2011 Aug;107(2):171-9. (abstract)
• Hudelson PM, Junod-Perron N, Perneger TV. Using clinical vignettes to assess doctors’ and students’ ability to identify socio-cultural factors affecting health and health care. Med Teach 2011 2011;33(10) (abstract)
• Hudelson PM, Junod Perron N, Perneger T. Self-assessment of intercultural communication skills: a survey of physicians and medical students in Geneva, Switzerland. BMC Med Educ 2011;11:63. (abstract)
• Kundig F, Staines A, Kinge T, Perneger TV. Numbering questionnaires had no impact on the response rate and response content of a patient safety culture survey: randomized trial. J Clin Epidemiol 2011;64:1262-5 (abstract)
• Lebreton A, Lapalud P, Chambost H, Biron-Andréani C, Morange PE, Combescure C, Marquès-Verdier A, Berger C, Schved JF, Granier C, Lavigne-Lissalde G. Prevalence and epitope specificity of non-neutralising antibodies in a large cohort of haemophilia A patients without inhibitors. Thromb Haemost. 2011 Jun 6;105(6):954-61. Epub 2011 Apr 7.
• Lavigne JP, Boutet-Dubois A, Laouini D, Combescure C, Bouziges N, Marès P, Sotto A. Virulence Potential of Escherichia coli Strains Causing Asymptomatic Bacteriuria during Pregnancy. J Clin Microbiol. 2011 Nov;49(11):3950-3. Epub 2011 Sep 14. (abstract)
• L’Huillier AG, Ferry T, Courvoisier DS, et al. Impaired antibody memory to varicella-zoster virus in HIV-infected children: low antibody levels and avidity. HIV Medicine. (abstract)
• Mamie C, Clergue F, Zocatelli D, Haller G. Swiss healthcare cost containment policies and their impact on anaesthetists’ density and satisfaction. Swiss Medical Weekly 2011. PMID: 21971666 (abstract) 
• Meier S, Bel M, L'huillier A, Crisinel PA, Combescure C, Kaiser L, Grillet S, Pósfay-Barbe K, Siegrist CA; H1N1 Epidemiology Study Group of Geneva. Antibody responses to natural influenza A/H1N1/09 disease or following immunization with adjuvanted vaccines, in immunocompetent and immunocompromised children. Vaccine. 2011 Apr 27;29(19):3548-57. (abstract)
• Momjian A, Courvoisier DS, Kiliaridis S, Scolozzi P. Reliability of computational measurement of the condyles on digital panoramic radiographs. Dentomaxillofac rad. PMID: 21960403 (abstract)
• Mohty B, Bel M, Vukicevic M, Nagy M, Levrat E, Meier S, Grillet S, Combescure C, Kaiser L, Chalandon Y, Passweg J, Siegrist CA, Roosnek E; Blood and Marrow Transplant Program; Geneva University Hospitals H1N1 study group. Graft-versus-host disease is the major determinant of humoral responses to the AS03-adjuvanted influenza A/09/H1N1 vaccine in allogeneic hematopoietic stem cell transplant recipients. Haematologica. 2011 Jun;96(6):896-904. Epub 2011 Mar 21. (article)
• Osih RB, Taffé P, Rickenbach M, Gayet-Ageron A, Elzi L, Fux C, Opravil M, Bernasconi E, Schmid P, Günthard HF, Cavassini M; Swiss HIV Cohort Study. Outcomes of patients on dual-boosted PI regimens: experience of the Swiss HIV cohort study. AIDS Res Hum Retroviruses. 2010 Nov;26(11):1239-46. Epub 2010 Oct 7. (abstract)
• Perneger TV, Schiesari L, Cullati S, Charvet-Bérard A. Does information about risks and benefits improve the decision-making process in cancer screening – randomized study. Cancer Epidemiol 2011. PMID: 21622043 (abstract)
• Perneger TV. Sharing raw data: another of Francis Galton’s ideas. BMJ 2011;342:d3035 (letter)
• Perneger TV, Agoritsas T. Doctors’ and patients’ susceptibility to framing bias: a randomized trial. J Gen Intern Med 2011;26:1411-7 (abstract)
• Poletti PA, Platon A, de Perrot T, Sarasin F, Andereggen E, Rutschmann O, Dupuis-Lozeron E, Perneger T, Gervaz P, Becker CD. Acute appendicitis: prospective evaluation of a diagnostic algorithm integrating sonography and low-dose CT to reduce the need of standard CT. Eur Radiol. PMID: 21805194 (abstract)
• Scolozzi P, Momjian A, Courvoisier DS. Dentofacial deformities treated according to a dento-skeletal analysis based on divine proportion: are the resulting faces de facto “divinely” proportioned? J Cranofac Surg. 2011;22(1):147-150. (abstract)
• Schouman T, Courvoisier DS, Imholz B, van Issum C, Scolozzi P. Computational area measurement of orbital floor fractures: Reliability, accuracy and rapidity. Eur J Radiol. (in press)
• Suva D, Haller G, Lübbeke A, Hoffmeyer P. Differential impact of a crew resource management program according to professional specialty. Am Journ Med Quality. 2011 (in press)
• Vazquez L, Nizam Al Din Y, Christoph Belser U, Combescure C, Bernard JP. Reliability of the vertical magnification factor on panoramic radiographs: clinical implications for posterior mandibular implants. Clin Oral Implants Res. 2011 Dec;22(12):1420-5. Epub 2011 Mar 21. (abstract)
• Villà S, Weber DC, Moretones C, Mañes A, Combescure C, Jové J, Puyalto P, Cuadras P, Bruna J, Verger E, Balañà C, Graus F. Validation of the new Graded Prognostic Assessment scale for brain metastases: a multicenter prospective study. Radiat Oncol. 2011 Mar 2;6:23. (abstract)
• Vuilleumier N, Pagano S, Lahlou K, Poncet A, Charbonney E, et al. (2011) Head-to-Head Comparison of Auto-Antibodies for Cardiovascular Outcome Prediction after Myocardial Infarction: a Prospective Study. J Clinic Experiment Cardiol 2:169.
• Walker UA, Courvoisier DS, Dudler J, et al. Do new biologics meet the unmet medical need in RA? Safety and efficacy of abatacept following B-cell depletion. Rheumatology (Oxford). 2011;50(1):243-244. (abstract)
• Zufferey A, Reny JL, Combescure C, de Moerloose P, Sanchez JC, Fontana P. Platelet reactivity is a stable and global phenomenon in aspirin-treated cardiovascular patients. Thromb Haemost. 2011 Sep;106(3):466-74. Epub 2011 Jul 4. (abstract)
• Zufferey G, Perneger T, Robert-Yap J, Skala K, Roche B. Accuracy of measurement of puborectal contraction by perineal ultrasound in patients with faecal incontinence. Colorectal Dis 2011;13:e234-7 (abstract)

2010

• Allegranzi B, Sax H, Bengaly L, Richet H, Minta DK, Chraiti MN, Sokona FM, Gayet-Ageron A, Bonnabry P, Pittet D; World Health Organization "Point G" ProjectManagement Committee. Successful implementation of the World Health Organization hand hygiene improvement strategy in a referral hospital in Mali, Africa. Infect Control Hosp Epidemiol. 2010 Feb;31(2):133-41. (abstract)
• Andersen E, Dessaix IM, Perneger T, Mombelli A. Myeloid-related protein (MRP8/14) expression in gingival crevice fluid in periodontal health and disease and after treatment. J Periodontal Res 2010 (abstract)
• Assal M, Che Ahmad A, Courvoisier DS, et al. Step activity monitoring to assess ambulation before and after total ankle arthroplasty. Foot and Ankle Surgery;19.03. 2010. (abstract)
• Baillet A, Zeboulon N, Gossec L, Combescure C, Bodin LA, Juvin R, Dougados M, Gaudin P. Efficacy of cardiorespiratory aerobic exercise in rheumatoid arthritis: meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2010 Jul;62(7):984-92 (abstract)
• Cartoni R, Arnaud E, Médard JJ, Poirot O, Courvoisier DS, Chrast R, Martinou JC. Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot–Marie–Tooth neuropathy type 2A. Brain 2010;133:1460-9. (abstract)
• Casanova N, Mazouni Z, Bieri S, Combescure C, Pica A, Weber DC. Whole brain radiotherapy with a conformational external beam radiation boost for lung cancer patients with 1-3 brain metastasis: a multi institutional study. Radiat Oncol. 2010 Feb 18;5:13. (abstract)
• Ceriani E, Combescure C, Le Gal G, Perneger T, Bounameaux H, Perrier A, Righini M. Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis. J Thromb Heamost 2010 (abstract)
• Combescure C, Fontana P, Mallouk N, Berdague P, Labruyere C, Barazer I, Gris JC, Laporte S, Fabbro-Peray P, Reny JL; CLOpidogrel and Vascular ISchemic Events Meta-analysis Study Group. Clinical implications of clopidogrel non-response in cardiovascular patients: a systematic review and meta-analysis. J Thromb Haemost. 2010 May;8(5):923-33. (abstract)
• Courvoisier DS, Renaud O. Robust analysis of the central tendency, simple and multiple regression and ANOVA: A step by step tutorial. International Journal of Psychological Research 2010;3:79-88 (article)
• Courvoisier DS, Etter JF. Comparing the predictive validity of five cigarette dependence questionnaires. Drug and Alcohol Dependence 2010;107: 128-33. (abstract)
• Courvoisier DS, Eid M, Lischetzke T, Schreiber WH. Psychometric Properties of a Computerized Mobile Phone Method for Assessing Mood in Daily Life. Emotion 2010 Feb;10(1):115-24. (abstract)
• Deom M, Agoritsas T, Perneger TV. What doctors think about the impact of managed care tools on quality of care, costs, autonomy, and relations with patients. BMC Health Services Res 2010;10:331 (article)
• Fouque-Aubert A, Jette-Paulin L, Combescure C, Basch A, Tebib J, Gossec L. Serious infections in patients with Ankylosing Spondylitis with and without TNF blockers: A systematic review and meta-analysis of randomized placebo-controlled trials. Ann Rheum Dis. 2010 Oct;69(10):1756-61 (abstract)
• Eid M, Courvoisier DS, Lischetzke T. A structural equation modeling approach to analyzing daily life data. Handbook of research methods in daily life. Guilford Press (in press)
• Finckh A, Ciurea A, Brulhart L, Moller B, Walker UA, Courvoisier DS, et al. Which subgroup of rheumatoid arthritis patients benefits from switching to rituximab versus alternative anti-TNF agents after previous failure to anti-TNF agent ? Ann Rheum Dis. 2010 Feb;69(2):387-93.(abstract)
• Gayet-Ageron A, Agoritsas T, Combescure C, Bagamery K, Courvoisier DS, Perneger TV. What differences are detected by superiority trials or ruled out by noninferiority trials? A cross-sectional study on a random sample of two-hundred two-arms parallel group randomized clinical trials. BMC Med Res Methodol 2010;10:93 (abstract)
• Geiser C, Eid M, Nussbeck FW, Courvoisier DS, Cole DA. Multitrait-Multimethod Change Modeling. AStA Advances in Statistical Analysis, Springer, vol. 94(2), pages 185-201, June.
• Geiser C, Eid M, Nussbeck FW, Courvoisier DS, Cole DA. Analyzing True Change in Longitudinal Multitrait-Multimethod Studies: Application of a Multimethod Change Model to Depression and Anxiety in Children. Developmental Psychology, 46(1), 29-45. (abstract)
• Gervaz P, Inan I, Perneger T, Schiffer E, Morel P. A prospective, randomized, single-blind comparison of laparoscopic versus open sigmoid colectomy for diverticulitis. Ann Surg 2010;252:3-8 (abstract)
• Grazioli S, Parvex P, Merlini L, Combescure C, Girardin E. Antenatal and postnatal ultrasound in the evaluation of the risk of vesicoureteral reflux. Pediatr Nephrol. 2010 Sep;25(9):1687-92. Epub 2010 Jun 4. (abstract)
• Griesser AC, Vlastos G, Morel L, Beaume C, Sappino AP, Haller G. Socio-demographic predictors of high support needs in newly diagnosed breast cancer patients. Eur J Cancer Care 2010; May 10 (abstract)
• Haller G, Camparini-Righini N, Kern C, Pfister RE, Morales M, Berner M, Clergue F, Irion O. Patient safety indicators for obstetrics: A Delphi based study. J Gynecol Obstet Biol Reprod 2010;39(5):371-378 (abstract)
• Haller C, Courvoisier DS. Personality and thinking style in different creative domains. Psychology of Aesthetics, Creativity, and the Arts. Volume 4, Issue 3, August 2010; 149-160. (abstract)
• Haller, C., Courvoisier, D. S., Cropley, D., & Cropley, A. Correlates of creativity among visual art students. International Journal of Creativity and Problem Solving 2010;20:53-71.
• Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T, Tenke P, Sotto A, Lavigne JP. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010 Apr 14;10:94 (abstract)
• Hudelson PM, Junod-Perron N, Perneger TV. Attitudes of physicians and medical students toward caring for immigrant patients. Eval Health Prof. 2010 Dec;33(4):452-72. (abstract)
• Hudelson P, Kolly V, Perneger T. Patients’ perceptions of discrimination during hospitalization. Health Expectations 2010;13:24-32 (abstract)
• Landes U, Robert J, Perneger T, Mentha G, Ott V, Morel P, Gervaz P. Predicting survival after pulmonary metastasectomy for colorectal cancer: previous liver metastases matter. BMC Surgery 2010;10:17 (article)
• Merlini L, Combescure C, De Rosa V, Anooshiravani M, Hanquinet S. Diffusion-weighted imaging findings in Perthes disease with dynamic gadolinium-enhanced subtracted (DGS) MR correlation: a preliminary study. Pediatr Radiol. 2010 Mar;40(3):318-25. (abstract) 
• Montecucco F, Lenglet S, Gayet-Ageron A, Bertolotto M, Pelli G, Palombo D,Pane B, Spinella G, Steffens S, Raffaghello L, Pistoia V, Ottonello L, Pende A,Dallegri F, Mach F. Systemic and intraplaque mediators of inflammation are increased in patients symptomatic for ischemic stroke. Stroke. 2010Jul;41(7):1394-404. Epub 2010 Jun 10. (abstract)
• Myles PS, Haller G. Global distribution of access to surgical services. Lancet 2010; Jun 30 (abstract)
• Perneger TV, Courvoisier DS. Interpretation of evidence in data by untrained medical students: a scenario-based study. BMC Med Res Methodol 2010;10:78 (article)
• Perneger TV. Citation analysis of identical consensus statements revealed journal-related bias.  J Clin Epidemiol 2010 Jun;63(6):660-4. Epub 2010 Jan 25. (abstract)
• Perneger, T. V., Courvoisier, D. S., & Combescure, C. General population reference values for the French version of the EuroQol EQ-5D health utility instrument. Value Health. 2010 Aug;13(5):631-5. (abstract)
• Perneger TV, Cullati S, Schiesari S, Charvet-Bérard A. Impact of information about risks and benefits of cancer screening on intended participation. Eur J Cancer 2010 Aug;46(12) : 2267-74 (abstract)
• Perneger TV. Speed trends of major cycling races: does slower mean cleaner? Int J Sports Med 2010 Feb;31:261-4 (abstract)
• Peytremann-Bridevaux I, Kolly V, Perneger TV. The association between body mass index and patients’ experiences with inpatient care. Int J Qual Health Care 2010 Apr;22(2):140-4 (abstract)
• Schwenter F, Poletti PA, Platon A, Perneger TV, Morel P, Gervaz P. A clinico-radiological score for predicting the risk of strangulated small bowel obstruction. Br J Surg 2010 (abstract)
• Sotto A, Richard JL, Combescure C, Jourdan N, Schuldiner S, Bouziges N, Lavigne JP. Beneficial effects of implementing guidelines on microbiology and costs of infected diabetic foot ulcers. Diabetologia. 2010 Oct;53(10):2249-55. Epub 2010 Jun 23 (abstract)
• Vasalou A, Joinson AN, Courvoisier DS. Unpacking the nature of “true commitment” in Facebook. Journal of Human-Computer Studies 2010;68:719-28.
• Walker UA, Courvoisier DS, Dudler J, Äberli D, von Kempis J, Finckh A. Do new biologics meet the unmet medical need in RA? Safety and efficacy of abatacept following B-cell depletion. Rheumatology (Oxford). 2010 Aug 17. [Epub ahead of print] (abstract)

2009

• A Calmy, A Gayet-Ageron, F Montecucco, A Nguyen, F Mach, F Burger, S Ubolyam, A Carr, K Ruxungtham, B Hirschel, J Ananworanich, on behalf of the STACCATO Study Group. HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial. AIDS 2009 May 15;23(8):929-39. (abstract)
• Agoritsas T, Lubbeke A, Schiesari L, Perneger TV. Assessment of patients’ tendency to give a positive or negative rating to health care. Qual Saf Health Care. 2009 Oct;18(5):374-9. (abstract)
• Beyer K, Taffé P, Halfon P, Pittet V, Pichard S, Haller G ,Burnand B. Hypertension and Intra-operative Incidents. A Study of 125 000 Anaesthesias in Swiss Hospitals. Anaesthesia 2009;64:494-502 (abstract)
• Bosshard V, Roux-Lombard P, Perneger T, Metzger M, Vivien R, Rochat T, Janssens JP. Do results of the T-SPOT.TB interferon gamma release assay change after treatment of tuberculosis ? Respir Med 2009;103:30-4 (abstract)
• C Combescure, N Vallier, B Ledergerber, M Cavassini, H Furrer, A Rauch, M Battegay, E Bernasconi, P Vernazza, B Hirschel and the Swiss HIV Cohort Study.How reliable is an undetectable viral load? HIV Medicine 2009 Sep;10(8):470-6. (abstract)
• Chamot E, Charvet A, Perneger TV. Overuse of mammography during the first round of an organized breast cancer screening programme. J Eval Clin Pract. 2009 Aug;15(4):620-5 (abstract)
• C. Lysakowski, N. Elia, C. Czarnetzki, L. Dumont, G. Haller, C. Combescure, M. R. Tramèr. Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients. Br J Anaesth. 2009 Jun 19. (abstract)
• Courvoisier DS, Eid M, Lischetzke T, Schreiber WH. Psychometric Properties of a Computerized Mobile Phone Method for Assessing Mood in Daily Life. Emotion (in press)
• Courvoisier DS, Perneger TV. Validation of alternative formulations of job strain. J Occup Health. 2009 Nov 13 (abstract) 
• Cullati S, Charvet-Bérard AI, Perneger TV. Cancer screening in a middle-aged general population: factors associated with practices and attitudes. BMC Public Health 2009, 9:118. (abstract - article)
• Daurès MF, Combescure C, Demattei C, Cristol JP. Mesure de l’hématocrite : comparaison de la conductimétrie à la microcentrifugation. Ann Biol Clin (Paris). 2009 Jan-Feb;67(1):67-72. (abstract)
• Emmanuel Somm, Valérie M. Schwitzgebel, Audrey Toulotte, Christopher R. Cederroth, Christophe Combescure, Serge Nef, Michel L. Aubert, and Petra S. Hüppi. Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat. Environmental Health Perspectives Volume 117, Number 10, October 2009 (abstract)
• Escher M, Perneger TV, Chevrolet JC. Admission of incompetent patients to intensive care : doctors’ responsiveness to family wishes. Crit Care Med 2009;37:528-32 (abstract)
• Etter JF, Huguelet P, Perneger TV, Cornuz J. Nicotine gum treatment before smoking cessation : a randomized trial. Arch Intern Med. 2009 Jun 8;169(11)1028-34. (abstract)
• F Banal, M Dougados, C Combescure, L Gossec. Sensitivity and specificity of the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid arthritis according to disease duration: a systematic literature review and meta-analysis. Annals of the Rheumatic Diseases 2009;68:1184-1191. (abstract)
• Gay P, Courvoisier DS, Billieux J, Rochat L, Schmidt RE, Van der Linden M. Can the distinction between intentional and unintentional interference control help differentiate varieties of impulsivity? Journal of Research in Personality. 15 Octobre 2009. (abstract)
• Gayet-Ageron A, Ninet B, Toutous-Trellu L, Lautenschlager S, Furrer H, Piguet V, Schrenzel J, Hirschel B. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. Sex Transm Infect. 2009 Jan 20. (abstract)
• Geiser C, Eid M, Nussbeck FW, Courvoisier DS, Cole DA. Multitrait-Multimethod Change Modeling. Archives of Statistical Analysis. (in press)
• Haller G, Myles PS. Using an incident reporting system to improve anaesthetic care: a study on undesirable events at the beginning of a new year. Australian New Zealand College of Anaesthetists Bulletin. December 2009 (in press)
• Haller G, Myles P, Taffé P, Perneger T, Wu C . Increase in the rate of undesirable events at the beginning of the academic year: a universal problem. BMJ 2009;339:b3974 (abstract)
• Haller G, Stoelwinder J, Myles P, McNeil J. Quality and Safety Indicators in Anesthesia: a systematic review. Anesthesiology. 2009;110(5):1158-75. (abstract)
• Haller G, Myles PS, Taffé P, Perneger TV, Wu CL. Rate of undesirable events at beginning of academic year: retrospective cohort study. BMJ. 2009 Oct 13;339:b3974. (abstract)
• Haller G, Haller DM, Courvoisier DS, Lovis C. Handheld versus laptop computers for electronic data collection in clinical research: a cross-over randomized trial. J Am Med Inform Assoc 2009;16(5):651-659.(abstract)
• Hudelson P, Kolly V, Perneger T. Patients' perceptions of discrimination during hospitalization. Health Expect. 2009 Sep 24. (abstract)
• Jacques Sany, Jean-David Cohen, Christophe Combescure, Marie-Cécile Bozonnat, Françoise Roch-Bras, Georges Lafon and Jean-Pierre Daurès. Medico-economic evaluation of infliximab in rheumatoid arthritis—prospective French study of a cohort of 635 patients monitored for two years. Rheumatology 2009 48(10):1236-1241. (abstract)
• J Paccou, N Zeboulon, C Combescure, L Gossec, B Cortet. The prevalence of osteoporosis, osteopenia and fractures among adults with cystic fibrosis: a systematic literature review with meta-analysis. Calcified Tissue International 2009 Dec 1. (abstract) 
• Junod Perron N, Perneger T, Kolly V, Dominice Dao M, Sommer J, Hudelson P. Use of a computer-based simulated consultation tool to assess whether physicians explore sociocultural factors during patient evaluation. J Eval Clin Pract 2009;15:1190-5 (abstract)
• Lallemant B, Evrard A, Combescure C, Chapuis H, Chambon G, Raynal C, Reynaud C, Sabra O, Joubert D, Hollande F, Lallemant JG, Lumbroso S, Brouillet JP. Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse. BMC Cancer. 2009 Oct 18;9:370. (abstract)
• Lallemant B, Evrard A, Combescure C, Chapuis H, Chambon G, Raynal C, Reynaud C, Sabra O, Joubert D, Hollande F, Lallemant JG, Lumbroso S, Brouillet JP. Reference gene selection for head and neck squamous cell carcinoma gene expression studies. BMC Mol Biol. 2009 Aug 3;10:78. (abstract)
• Lübbeke A, Suvà D, Perneger T, Hoffmeyer P. Influence of preoperative patient education on the risk of dislocation after primary total hip arthroplasty.Arthritis Rheum. 2009 Apr 15;61(4):552-8 (abstract)
• Laura Merlini, Christophe Combescure, Vincenzo De Rosa, Mehrak Anooshiravani, Sylviane Hanquinet. Diffusion imaging findings in Perthes disease with dynamic gadolinium enhanced subtracted (DGS) MR correlation. A pilot study. Pediatric Radiology (in press)
• Lubbeke-Wolff A, Suva D, Perneger TV, Hoffmeyer P. Effect of patient education on the dislocation of the hip after total hip arthroplasty. Arthritis Care Res 2009 (in press)
• Mariotti N, Moralès M, Haller G. An uncommon cause of dyspnea during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2009 Oct 28 (abstract)
• Nussbeck FW, Eid M, Geiser C, Courvoisier DS, Lischetzke T. A CTC(M-1) Model for Different Types of Raters. Methodology 2009;5(3):88-98.(abstract)
• O. Keiser, A. Spoerri, MWG. Brinkhof, B. Hasse, A. Gayet-Ageron, F. Tissot, A. Christen, M. Battegay, P. Schmid, E. Bernasconi, M. Egger. Suicide in HIV-infected individuals and the general population, Switzerland 1988-2008. Am J Psy 2009 (abstract)
• Perneger TV. Citation analysis of identical consensus statements revealed journal-related bias. J Clin Epidemiol (in press)
• Philippe-Jean Bousquet, MD, Christophe Combescure, PhD, Jean-Michel Klossek, MD, Jean-Pierre Daure` s, MD, and Jean Bousquet, MD. Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis. J Allergy Clin Immunol. 2009 Apr 13. (abstract)
• Pica A, Miller R, Villa S, Kadish S, Anacak Y, Abusaris H, Ozyigit G, Baumert B, Zaucha R, Haller G, Weber D. The Results of Surgery, with or without Radiotherapy, for Primary Spinal Myxopapillary ependymoma: a Retrospective Study from the Rare Cancer Network. Int J Radiat Oncol Biol Phys 2009; 74(4):1114-20 (abstract)
• R. Nüesch, A. Gayet-Ageron, Chetchotisakd P, Prasithsirikul W, Kiertiburanakul S, Munsakul W, Raksakulkarn P, Tansuphasawasdikul S, Chautrakarn S, Ruxrungtham K, Hirschel B, Anaworanich J; the STACCATO study group. The Impact of Combination Antiretroviral Therapy and its Interruption on Anxiety, Stress, Depression and Quality of Life in Thai Patients. Open AIDS J 2009; 3:38-45. (abstract)
• Schmidt RE, Gay P, Courvoisier DS, Jermann F, Ceschi G, David M, et al. Anatomy of the White Bear Suppression Inventory (WBSI): A Review of Previous Findings and a New Approach. Journal of Personality Assessment 2009;91(4):323-330. (in press)
• Sherman H, Castro G, Fletcher M, Hatlie M, Hibbert P, Jakob R, Koss R, Lewalle P, Loeb J, Perneger T, Runciman W, Thomson R, van der Schaaf T, Virtanen M. Towards an International Classification for Patient Safety : the conceptual framework. Int J Qual Health Care 2009;21:2-8. (article)
• Triverio PA, Martin PY, Romans J, Pugin J, Perneger T, Saudan P. Long term prognosis after acute kidney injury requiring replacement therapy. Nephrol Dial Transplant. 2009 Jul;24(7):2186-9. (abstract)
• Vuilleumier N, Le Gal G, Verschuren F, Perrier A, Bounameaux H, Turck N, Sanchez JC, Mensi N, Perneger T, Hochstrasser D, Righini M. Cardiac biomarkers for risk stratification in non-massive pulmonary embolism : a multicenter prospective study. J Thromb Heamost 2009;7:391-8 (abstract)
• Yerly S, Junier T, Gayet-Ageron A, Boffi-El Amari E, Günthard HF, Hirschel B, Zdobnov E, Kaiser L. The impact of transmission clusters on primary drug resistance in newly diagnosed HIV-1 infection. AIDS 2009 Jul 17;23(11):1415-23. (abstract)
• Zufferey G, Perneger T, Robert-Yap J, Rubay R, Lkhagvabayar B, Roche B. Measure of the voluntary contraction of the puborectal sling as a predictor of successful sphincter repair in the treatment of anal incontinence. Dis Colon Rectum. 2009 Apr;52(4):704-10 (abstract)

2008

• A. Gayet-Ageron, B. Poncet, P. Guerre, L. Rocher, E. Dureau-Drevard, C. Colin, J. Orgiazzi, M. Berland, S. Touzet. Specific information about the WHO guidelines for gestational diabetes screening improve clinical practices. J Eval Clin Pract 2008 ;14 :36-42. (abstract)
• Charvet-Bérard A, Chopard P, Perneger TV. Measuring quality of patient information documents with an expanded EQIP scale. Patient Educ Couns 2008;70:407-11 (abstract)
• Courvoisier DS, & Etter JF. Using item response theory to study convergent and discriminant validity of three questionnaires measuring cigarette dependence. Psychol Addict Behav. 2008 Sep;22(3):391-401. (abstract)
• Courvoisier DS, Nussbeck FW, Eid M, Geiser C, Cole DA. Analyzing the convergent and discriminant validity of states and traits: development and applications of multimethod latent state-trait models. Psychological Assessment 2008;20(3):270-80. (abstract) 
• E. Boffi-El Amari, L. Toutous-Trellu, A. Gayet-Ageron, M. Baumann, G. Cathomas, I. Steffen, P. Erb, NJ. Mueller, HJ. Furrer, M. Cavassini, P. Vernazza, HH. Hirsch, E. Bernasconi, B. Hirschel. Predicting the evolution of Kaposi sarcoma in the highly active retroviral therapy era. AIDS 2008 ;22 :1019-28.(article)
• Felley C, Perneger TV, Goulet I, Rouillard C, Azar-Pey N, Dorta G, Hadengue A, Frossard JL. Combined written and oral information prior to gastrointestinal endoscopy compared with oral information alone: a randomized trial. BMC Gastroenterol. 2008 Jun 3;8:22. (abstract)
• Haller G, Morales M, Pfister R, Garnerin P, Chipp P, Millart V, Guillemot V,Berner M, Irion O, Clergue F, Kern C. Improving interprofessional teamwork in obstetrics: a Crew Resource Management based training program. Journal of Interprofessional Care 2008; 22(5): 1–4 (abstract - article)
• Haller G, Garnerin P, Morales MA, Pfister R, Berner M, Irion O, Clergue F, Kern C. Effect of crew resource management training in a multidisciplinary obstetrical setting. Int J Qual Health Care. 2008 Aug;20(4):254-63. (abstract)
• Haller G, Myles PS, Langley M, Stoelwinder J, McNeil J. Assessment of an unplanned admission to the intensive care unit as a global safety indicator in surgical patients. Anaesth Intensive Care. 2008 Mar;36(2):190-200. (abstract)
• Hudelson P, Cleopas A, Kolly V, Chopard P, Perneger TV. What is quality and how is it achieved? Practitioners’ views vs. quality models. Qual Saf Health Care 2008;17:31-6. (abstract) 
• J. Ananworanich, A. Gayet-Ageron, K. Ruxringtham, P. Chetchotisakd, W. Prasithsirikul, S. Kiertiburanakul, W. Munsakul, P. Raksakulkarn, S. Tansuphasawadikul, M. Le Braz, T. Jupimai, S. Ubolyam, M. Schutz, B. Hirschel. Long-term efficacy and safety of first-line therapy with once-daily saquinavir/ritonavir. Antivir Ther 2008 ;13 :375-80. (abstract)
• Keiser O, Gayet-Ageron A, Rudin C, Brinkhof MW, Gremlich E, Wunder D, Drack G, Hirschel B, de Tejada BM; Swiss HIV Cohort Study (SHCS); Swiss Mother & Child HIV Cohort Study (MoCHiV). Antiretroviral treatment during pregnancy. AIDS. 2008 Nov 12;22(17):2323-30 (abstract)
• Louis-Simonet M, Kossovsky MP, Chopard P, Sigaud P, Perneger TV, Gaspoz JM. A predictive score to identify hospitalized patients’ risk of discharge to a post-acute care facility. BMC Health Serv Res. 2008 Jul 22;8:154. (abstract) 
• Nguyen A, Calmy A, Schiffer V, Bernasconi E, Battegay M, Opravil M, Evison JM, Tarr PE, Schmid P, Perneger T, Hirschel B; the Swiss HIV Cohort Study. Lipodystrophy and weight changes: data from the Swiss HIV Cohort Study, 2000-2006. HIV Med 2008 Mar;9(3):142-150. (abstract)
• Perneger TV. Estimating the relative hazard by the ratio of logarithms of event-free proportions. Contemp Clin Trials. 2008 Sep;29(5):762-6. (abstract) 
• Perneger TV, Charvet-Bérard A, Perrier A. Patient assessments of the most important medical decision during hospitalization. J Gen Intern Med. 2008 Oct;23(10):1659-65. (abstract) 
• Righini M, Le Gal G, Aujesky D, Roy PM, Sanchez O, Verschuren F, Rutschmann O, Nonent M, Cornuz J, Thys F, Petit Le Manach C, Revel MP, Poletti PA, Meyer G, Mottier D, Perneger T, Bounameaux H, Perrier A. Diagnosis of pulmonary embolism by multidetector CT alone or combined with venous ultrasonography of the leg: a randomised non-inferiority trial. Lancet. 2008 Apr 19;371(9621):1343-52. (abstract)
• Saudan P, Kossovsky MP, Martin PY, Perneger TV. Quality of care and survival of hemodialysed patients in Western Switzerland. Nephrol Dial Transplant 2008 Jun;23(6):1975-81. (abstract) 
• S. Langford, A. Gayet-Ageron, C. Duncombe, T. Jupimai, P, A. Mahanontharit, S. Kiertiburanakul, W. Munsakul, K. Ruxrungtham, , B. Hirschel, J. Ananworanich. Supersensitive viral load assay in predicting CD4-guided treatment failure. Open Virol 2008; 2:69-73.(abstract)
• Sotto A, Lina G, Richard JL, Combescure C, Bourg G, Vidal L, Jourdan N, Etienne J, Lavigne JP. Virulence potential of Staphylococcus aureus strains isolated from diabetic foot ulcers: a new paradigm. Diabetes Care. 2008 Dec;31(12):2318-24. Epub 2008 Sep 22. (abstract)
• Verdon M, Merlani P, Perneger T, Ricou B. Burnout in a surgical ICU team. Intensive Care Med 2008 Jan;34(1):152-6. (abstract)
• Weber D, Zilli T, Buchegger D, Casanova N, Haller G, Rouzaud D, Nouet P, Dipasquale, G Ratib O, Zaidi H, Vees H, Miralbell R. [(18)F]Fluoroethyltyrosine- Positron Emission Tomography-Guided Radiotherapy for High-Grade Glioma. Radiat Oncol. 2008 Dec 24; 3:44-4

2007

• Garnerin P, Pellet-Meier B, Chopard P, Perneger T, Bonnabry P. Measuring human-error probabilities in drug preparation: a pilot simulation study. Eur J Clin Pharmacol. 2007 Aug;63(8):769-76. (abstract) 
• Garnerin P, Perneger T, Chopard P, Ares M, Baalbaki R, Bonnabry P, Clergue F. Drug selection errors in relation to medication labels: a simulation study. Anaesthesia. 2007 Nov;62(11):1090-4. (abstract)
• Haller G, Myles PS. Regional block and cancer recurrence: too early to tell. Anesthesiology. 2007 Aug;107(2):354; (abstract)
• Haller G, Myles PS, Stoelwinder J, Langley M, Anderson H, McNeil J. Integrating incident reporting into an electronic patient record system. J Am Med Inform Assoc. 2007 Mar-Apr;14(2):175-81. (abstract)
• Lopez U, Habre W, Laurençon M, Haller G, Van der Linden M, Iselin-Chaves IA. Intra-operative awareness in children: the value of an interview adapted to their cognitive abilities. Anaesthesia. 2007 Aug;62(8):778-89. (abstract) 
• Micheli P, Kossovsky MP, Gerstel E, Louis-Simonet M, Sigaud P, Perneger TV, Gaspoz JM. Patients’ knowledge of drug treatments after hospitalisation: the key role of information. Swiss Med Wkly. 2007 Nov 3;137(43-33):614-20. (abstract) 
• Packard RR, Schlegel S, Senouf D, Burger F, Sigaud P, Perneger T, Siegrist CA, Mach F. Atorvastatin treatment and vaccination efficacy. J Clin Pharmacol. 2007 Aug;47(8):1022-7. (abstract) 

Editos

2009

• Perneger T. Parting shots. Int J Qual Health Care. 2009;21(2):77-78. (extract)

2008

• Perneger TV. Quality as a field of research: what we published, 2004-2007. Int J Qual Health Care. 2008;20(3):153-4. (extract)
• Perneger TV. The Council of Europe recommendation Rec(2006)7 on management of patient safety and prevention of adverse events in health care. Int J Qual Health Care 2008;20:305-7. (extract) 

2007

• Perneger TV, Hudelson PM. How international is the International Journal of Quality in Health Care? Int J Qual Health Care 2007;19(6):329-333. (extract)
• Hirschel B, Perneger TV. No patient left behind - better treatments for resistant HIV infection. Lancet 2007;370:3-5. (extract)

Le service d'épidémiologie clinique fournit un soutien méthodologique aux projets de recherche clinique dans le cadre du Centre de Recherche Clinique. Il aide la direction médicale à évaluer l’impact des services de santé, les programmes de soins transversaux et les interventions visant à améliorer les soins. Enfin il assure le développement et la validation d’outils et de méthodes destinés à l’évaluation en santé et étudier le processus de recherche clinique au sein des HUG.

Découvrez le site d'épidémiologie clinique,  où sont présentés tous les domaines d'activité, de recherche et d'enseignement dans lesquels il est impliqué.

Regrets liés à la prise en charge des patients et qualité des soins

Ce programme de recherche est composé de 4 étapes:

1. Qu'est-ce que le regret lié à une prise en charge patient ? Est-ce lié toujours lié à une erreur, ou non ? Une étude qualitative a permis d'explorer le vécu des soignants et de comprendre les stratégies mentales de gestion de leurs regrets.

Voir également: Courvoisier DS et al., "Experiencing regrets in clinical practice", The Lancet 2013, 382(9904): 1553-1554 [Pubmed]

2. Comment mesurer le regret lié à une prise en charge patient et les stratégies mentales de gestion des regrets ? Une étude de validation a été conduite afin de construire deux questionnaires, l'un mesurant l'intensité du regret le plus important, l'autre mesurant les stratégies mentales de gestion des regrets quotidiens (publication in press).

Projets en cours:

1) avec la collaboration d'Intermountains Healthcare (Salt Lake City, Utah, Etats-Unis), une étude de validation de la traduction anglaise des deux questionnaires est en cours. Le projet contient trois phases: a) étude qualitative pour adapter culturellement les items du questionnaires, b) traduction des items (backward et forward), c) enquête avec test-retest. Le projet est conduit avec Glen McBride et Pascal Briot.

2) avec la collaboration du Triemli Hospital (Zürich), une étude de validation de la traduction allemande des deux questionnaires est en cours. Le projet est conduit avec Dr. Silvia Richner et Prof. Christoph Meier.

Les prochaines étapes dans le futur seront les suivantes:

3. Comment les regrets influencent la santé mentale des soignants ? (demande de financement en cours d'évaluation)

4. Est-ce qu'une formation aux techniques mentales de gestion des regrets améliore la santé mentale des soignants ?

Implémentation de la checklist chirurgicale de sécurité dans les blocs opératoires en Suisse

En 2010, une enquête par questionnaire a été conduite dans deux congrès de chirurgie en Suisse. 

En 2013, cette enquête sera renouvellée, avec le même questionnaire. Les résultats seront disponibles en hiver 2013.

2014

• Courvoisier DS, Cullati S, Ouchi R, Schmidt RE, Haller G, Chopard P, Agoritsas T, Perneger TV, “Validation of a 15-item care-related regret regulation scale (RRS) for healthcare professionals”, Journal of Occupational Health, In Press
• Cullati S, Licker M, Francis P, Degiorgi A, Bezzola P, Courvoisier DS, Chopard P, "Implementation of the Surgical Safety Checklist in Switzerland and perceptions of its benefits: cross-sectional survey", PLoS ONE, 2014, 9(7): e101915. [Pubmed]
• Juge-Müller V, Cullati S, Blondon KS, Hudelson P, Maitre F, Vu NV, Savoldelli G, Nendaz M, "Interprofessional Collaboration between Residents and Nurses in General Interal Medicine: A Qualitative Study on Behaviours Enhancing Teamwork Quality", PLoS ONE, 2014, 9(4): e96160. [Pubmed]
• Junod Perron N, Cullati S, Hudelson P, Nendaz M, Dolmans D, Van der Vleuten CPM, “Impact of a faculty development programme for teaching communication skills on participants' practice”, Postgraduate Medical Journal, 2014, 90(1063): 245-50. [Pubmed]
• Perneger TV, Cullati S, Rudaz S, Agoritsas T, Schmidt RE, Combescure C, Courvoisier DS, “Effect of numbering of return envelopes on participation, explicit refusals, and bias: experiment and meta-analysis”, BMC Medical Research Methodology, 2014, 14(1): 6 [Pubmed]

2013

• Perneger TV, Combescure C, Gayet-Ageron A, Courvoisier DS, Agoritsas T, Cullati S, “Self-rated health: analysis of distances and transitions between response options” Qualify of Life Research, 2013, 22(10): 2761-2768. [Pubmed]
• Cullati S, Francis Gerstel P, Chopard P, "HUG: résultats de l'enquête de satisfaction auprès des médecins de ville", Lettre de l'Association des médecins du canton de Genève, n°3, Avril 2013, pp. 7-9. [Download]
• Cullati S, Le Du S, Raë AC, Micallef M, Khabiri E, Ourahmoune A, Boireaux A, Licker M, Chopard P, "Is the Surgical Safety Checklist successfully conducted? An observational study of social interactions in the operating rooms of a tertiary hospital.", BMJ Quality & Safety 2013, 22(8): 639-646. [Pubmed] [download]
• Juge-Müller V, Cullati S, Blondon KS, Hudelson P, Maitre F, Vu NV, Savoldelli G, Nendaz M, “Interprofessional Collaboration on an Internal Medicine Ward: Role Perceptions and Expectations among Nurses and Residents.”, PLoS ONE 2013, 8(2):e57550. [Pubmed]
• Courvoisier DS, Cullati S, Haller CS, Schmidt RE, Haller G, Agoritsas T, Perneger TV, “Validation of a 10-item care-related regret intensity scale (RIS-10) for healthcare professionals.”, Medical Care 2013, 51(3):285-291. [Pubmed]

2012

• Chopard P, “La sociologie peut-elle contribuer à améliorer la qualité des soins ?”, Bulletin de la Société Suisse de Sociologie / Bulletin of theSwiss Sociological Association, 2012, 142:30-32. [Download]
• Cullati S, “La collaboration scientifique entre sociologie et médicine : après les méthodes, les concepts ?”, Bulletin de la Société Suisse de Sociologie / Bulletin of theSwiss Sociological Association, 2012, 142:21-23. [Download]
• Perneger TV, Deom M, Cullati S, Bovier PA, “Le désenchantement croissant des médecins genevois.”, Bulletin des médecins suisses / Schweizerische Ärztezeitung / Bollettino dei medici svizzeri 2012, 93(24):921-923. [Download] 
• Perneger TV, Deom M, Cullati S, Bovier PA, “Growing discontent of Swiss doctors, 1998-2007.”, European Journal of Public Health 2012, 22(4):478-483. [Pubmed]

2011

• Courvoisier DS, Agoritsas T, Schmidt R, Pernerger TV, Cullati S, “Regrets associated with providing healthcare: qualitative study of experiences of hospital-based physicians and nurses”, PLoS ONE 2011, 6(8): e23138. [Pubmed]
• Cullati S, Courvoisier DS, Charvet-Bérard AI, Perneger TV, "Desire for autonomy in health care decisions: a general population survey", Patient Education and Counseling 2011, 83(1):134-138. [Pubmed]
• Thibault R, Chikhi M, Clerc A, Darmon P, Chopard P, et al., "Assessment of food intake in hospitalised patients: A 10-year comparative study of a prospective hospital survey." Clinical Nutrition 2011, 30(3):289-296. [Pubmed]

2010

• Nendaz MR, Chopard P, Lovis C, Kucher N, Asmis LM, Dörffler J, Spirk D, Bounameaux H, "Adequacy of venous thromboprophylaxis in acutely ill medical patients (IMPART): multisite comparison of different clinical decision support systems." J Thromb Haemost 2010, 8(6):1230-1234. [Pubmed]

2009

• Chopard P, Spirk D, Beer HJ, Peter J, Brunner B, Bounameaux H, Dörffler-Melly J (2009). "Swiss results from a global observational study of venous thromboembolism risk and prophylaxis use in the acute care hospital setting: analysis from the ENDORSE study." Swiss Med Wkly 139(43-44):630-635. [Pubmed]

2008

• Hudelson P, Cleopas A, Kolly V, Chopard P, Perneger TV, "What is quality and how is it achieved? Practitioners' views versus quality models." Quality & Safety in Health Care 2008, 17(1):31-36. [Pubmed]
• Charvet-Berard AI, Chopard P, Perneger TV, "Measuring quality of patient information documents with an expanded EQIP scale" Patient Education and Counseling, 2008, 70 (3):407-411. [Pubmed] 
• Louis Simonet M, Kossovsky MP, Chopard P, Sigaud P, Perneger TV, Gaspoz JM, "A predictive score to identify hospitalized patients' risk of discharge to a post-acute care facility." BMC Health Serv Res 2008, 8:154. [Pubmed] 

2007 and before

• Garnerin P, Perneger TV, Chopard P, et al., "Drug selection errors in relation to medication labels: a simulation study." Anaesthesia 2007, 62(11):1090-1094. [Pumbed]
• Garnerin P, Pellet-Meier B, Chopard P, Perneger TV, Bonnabry P. "Measuring human-error probabilities in drug preparation: a pilot simulation study." Eur J Clin Pharmacol 2007, 63(8):769-776. [Pubmed]
• Luthy C, Cedraschi C, Herrmann F, Kossovsky M, Perrin E, Chopard P, et al., "Appropriateness of hospital use: comparison between elderly patients' point of view and a structured questionnaire." Age & Ageing 2007, 36(6):681-684. [Pubmed]
• Chopard P, Spirk D, Bounameaux H, "Identifying acutely ill medical patients requiring thromboprophylaxis." J Thromb Haemost 2006, 4(4):915-916. [Pubmed]
• Chopard P, Dorffler-Melly J, et al., "Venous thromboembolism prophylaxis in acutely ill medical patients: definite need for improvement." J Intern Med 2005, 257(4):352-357. [Pubmed]
• Louis-Simonet M, Kossovsky MP, Sarasin FP, Chopard P, Gabriel V, Perneger TV, Gaspoz JM, "Effects of a structured patient-centered discharge interview on patients' knowledge about their medications." Am J Med 2004, 117(8):563-568. [Pubmed]
• Chmelik, P, Chopard P, Bounameaux H, "An evaluation of thromboembolism prophylaxis in acutely ill medical patients." Swiss Medical Weekly 2002, 132(35-36):513-516. [Pubmed]
• Kossovsky MP, Sarasin FP, Perneger TV, Chopard P, et al., "Unplanned readmissions of patients with congestive heart failure: do they reflect in-hospital quality of care or patient characteristics?" Am J Med 2000, 109(5):386-390. [Pubmed]
• Chopard P, Perneger TV, et al., "Predictors of inappropriate hospital days in a department of internal medicine." International Journal of Epidemiology 1998, 27(3):513-519. [Pubmed]
• Perneger TV, Chopard P, et al., "Risk factors for a medically inappropriate admission to a Department of Internal Medicine." Arch Intern Med 1997, 157(13):1495-1500. [Pubmed]

À l’image des HUG, le service de chirurgie thoracique et endocrinienne est impliqué dans la recherche fondamentale et la recherche directement appliquée au malade. Le but est de développer des stratégies diagnostiques et thérapeutiques performances et peu invasives.

Le service assure la prise en charge des patients avec l’apport des dernières technologies reconnues, ainsi que de nombreuses technologies novatrices dont il assure le développement. Cette activité de recherche n’est possible que grâce à un engagement permanent, une maitrise des coûts et au respect de la relation humaine avec le patient malgré une technologie importante et parfois impressionnante pour lui.

Projets de recherche en chirurgie thoracique

• Référentiels cancer poumon
• Améliorations de la chirurgie mini-invasive
• Évolution de la chirurgie d’exérèse pulmonaire vers les résections infra-lobaires
• Imagerie par fluorescence, aide novatrice d’utilisation routinière aux HUG (poumon)
• Laboratoire de recherche, mésothéliome
• Laser pour métastasectomies

Projets de recherche en chirurgie endocrinienne

• Référentiels de prise en charge des pathologies thyroïdiennes, parathyroïdiennes et surénaliennes
• Étude de la vascularisation parathyroidienne par imagerie par fluorescence
• Étude de l’apport de l’imagerie par fluorescnce pour la chirurgie des parathyroidiectomies sub-totales (hyperperathyroïdie secondaire ou tertiaire)

Vision de la Direction des soins dans le domaine de la recherche

La Direction des soins a établi un agenda de la recherche dont le but est de définir les axes prioritaires de la recherche en soins aux HUG, ainsi que de coordonner et guider les activités de recherche dans le domaine des soins.

Six axes sont définis : la qualité et la sécurité des soins, la gestion des symptômes, l’éducation thérapeutique et les comportements de santé, les interventions novatrices, la translation des bonnes pratiques dans les soins, l’organisation et la dispensation des soins.

La direction des soins soutient le développement d’une recherche scientifique appliquée dans le domaine des soins orientée patient, proches ou communauté. Par recherche appliquée, on entend une recherche dont le premier but est de développer de nouveaux savoirs dont les résultats sont utilisables dans la pratique des soins. La recherche en soins comprend les soins infirmiers, les sages-femmes, la physiothérapie, l’ergothérapie, la diététique, l’assistance sociale, la technique en radiologie médicale, l’animation, la psychomotricité et l’art-thérapie. Il s’agit d’une recherche relativement autonome qui est initiée et conduite par du personnel de soins.

Pour favoriser le développement de la recherche en soins aux HUG, la Direction des soins a :

• Un secteur recherche et qualité dont l’une des missions est de soutenir les projets de recherche et de développement émanant des milieux de pratiques.
• Un fonds de recherche qui permet de soutenir des projets émanant des milieux de pratique des HUG.
• Un programme de développement de la vie scientifique au sein des HUG.

Remise de traitement de substitution par héroïne dans des unités de soins généraux : état des lieux et perception des soignants (T. Musset et B. Rau)

Résumé :
Depuis un quinzaine d'années, des programmes de prescription médicale de diacétylmorphine (héroïne) ont été développés en Suisse. Ces traitements s'adressent à des patients chroniqument dépendants des opiacés illicites et qui présentent des comorbidités importantes. En cas d'hospitalisation en milieu somatique, la poursuite du traitement pose parfois des problèmes à des soignants peu ou pas formés en addictologie.

Ce travail propose de faire un "état des lieux" de la situation des patients hospitalisés à l'hôpital cantonal de Genève et d'explorer les perceptions des soignants qui ont été confrontés à ces situations de soins.

• Mission
• Equipe
• Zoom escarres
• Programme chutes
• Liens utiles

Mission

Définir des projets de recherche en soins infirmiers, ainsi que concevoir, gérer et/ou assurer la mise en œuvre de programmes d’évaluation et d’amélioration de la qualité des soins.

• Conception et pilotage de projets de recherche et qualité des soins, permettant l’amélioration et l’évolution des pratiques soignantes

Prévention des escarres; Prévention des chutes; Promotion de l'allaitement, rééducation des entorses de chevilles.

• Accompagnement et conseils méthodologiques auprès des cadres et des équipes soignants dans leurs projets de recherche et d’amélioration de la qualité
  
• Participation à des projets interdisciplinaires d’évaluation et d’amélioration de la qualité des soins

En collaboration, avec le service Qualité des Soins de la Direction médicale, analyse des incidents et des faits graves liés aux soins et développement de la gestion Informatique des déclarations d’incidents dans la perspective du retour d’expérience.

Activité de formation

Notre équipe intervient dans des programmes de formation pré / post gradués et formation continue. Les principaux domaines de compétences abordés sont la qualité des soins, la sécurité du patient, l’éthique et les recommandations de bonnes pratiques.

La consultation d'hémophilie des HUG participent à des projets de recherche de différentes façons :

• Jumelage/Twinning
• Etudes

Depuis octobre 2009 le jumelage entre le centre hospitalier de Yaounde (Pre Dora Mbanya) du Cameroun et les Hôpitaux Universitaires de Genève (Pr Philippe de Moerloose) a été mis en place et officiellement approuvé par la Fédération Mondiale des Hémophiles (FMH). Il s’agit d’un jumelage portant sur une durée de 4 ans pour lequel la FMH donne 1500 dollars par année.

Comment cette idée a germé et quels ont été les débuts ?

Basée sur notre expérience avec le Liban dont le jumelage fructueux était terminé, la FMH nous a contactés pour savoir si nous étions d’accord de faire un jumelage avec le centre hospitalier de Yaounde qui le souhaitait. Nous avons accepté, en particulier parce que la Faculté de Médecine de Genève a déjà beaucoup de liens avec la Faculté de Médecine de Yaounde (enseignement au Cameroun, formation de médecins du Cameroun à Genève, interventions chirurgicales, etc.).

Nous avons fait un premier voyage de deux jours en février 2009 pour voir comment la situation se présentait puis y sommes retournés avec la Dre F. Boehlen en novembre 2009 pour donner des conférences, voir des patients et discuter avec différentes autorités, dont le ministre de la santé. Le Dr. A. Haffar, un des directeurs de la FMH, était également présent.

Objectifs

Nous avons fixé 2 axes prioritaires pour les 4 ans à venir : le premier est d’établir une cartographie des maladies hémorragiques au Cameroun et le second étant la formation de médecins dans le domaine spécifique de l’hémostase.

• Le premier objectif consiste donc à faire un recensement des patients avec hémophilies et autres maladies hémorragiques héréditaires au Cameroun.

Ceci se fera de deux manières:

a) avec l’aide d’étudiants en médecine de Genève ainsi que de médecins de la Faculté de Genève connaissant déjà bien le Cameroun (Dr B. Stoll en particulier) ainsi que des médecins camerounais qui iront dans les différentes régions du Cameroun pour recenser les personnes souffrant de maladies hémorragiques;

b) en faisant une prise de sang qui doit nous permettre de faire un diagnostic. 
Cette deuxième partie du projet est possible grâce au soutien extrêmement précieux de la maison de diagnostic Stago (France) qui va fournir, en plus d’une machine de coagulation, des réactifs pour une période de trois ans. Petit rappel : au Cameroun qui compte 17 millions d’habitants, seulement 70 hémophiles sont recensés, au lieu des 1700 attendus, et les anomalies de la coagulation autres que l’hémophilie ne sont presque pas connues. Le fait de connaître le nombre de patients et leur affection va nous permettre d’envisager les besoins et, quand disponibles, d’administrer des traitements appropriés. 

• Le deuxième objectif est de pouvoir permettre une formation en hémostase à des professionnels de santé camerounaIS.

Grâce à un financement de la Fédération mondiale des hémophiles, nous allons accueillir pour un mois le Dr Cl. Tayou, spécialiste en hématologie, afin de se familiariser avec certaines techniques d’hémostase. Nous allons ensuite accueillir dès octobre 2010 la Dre Sylvie Moudourou de Yaounde pour faire une spécialisation complète en hématologie-hémostase qui durera 4 ans.

Pour la première année nous avons le soutien financier du Fonds Humanitaire des Hôpitaux Universitaires de Genève. Bien que cela ne soit pas facile, nous sommes optimistes pour trouver des fonds pour les années suivantes afin d’assurer la meilleure formation possible au Dre S. Moudourou.

Autres projets

En plus de ces deux axes (épidémiologie-diagnostic et formation), nous verrons dans quelle mesure un accès à la physiothérapie peut être facilité pour les patients souffrant de problèmes articulaires. Une physiothérapeute de Zürich, Andrea Bärlocher, nous a rejoints lors de notre seconde visite et grâce à elle nous nous sommes rendus compte une fois de plus combien une physiothérapie adaptée pouvait être d’une aide capitale pour la prise en charge de personnes souffrant de problèmes hémorragiques et de problèmes articulaires.

Nous souhaitons également chaque fois que possible amener des médicaments susceptibles de soulager les patients.

De plus, grâce à l’internet, nous pouvons procéder régulièrement à des échanges permettant entre autres de donner un avis médical et aussi d’échanger des informations utiles aux patients.

Remerciements

Un tel jumelage ne fonctionne qu’avec l’aide de différents appuis (FMH, implications de différents membres et soutien financier des Facultés et Hôpitaux de Médecine de Yaounde et de Genève). Nous voudrions également remercier, en plus de la maison Stago déjà mentionnée, la maison CSL-Behring qui non seulement a fait deux dons très importants de facteurs de coagulation mais aussi nous manifeste par différents échanges son soutien dans ce projet enthousiasmant mais difficile. La maison Bayer nous a également donné des facteurs de coagulation et nous lui en sommes très reconnaissants.

Les membres de l’Association Suisse des Hémophiles ont fait une récolte de fonds faite à Noël 2009. C’est un magnifique geste de solidarité.

Le centre de l’hémophilie de l’Unité d’hémostase des HUG, participe ou a participé à plusieurs études internationales dans le domaine de l’hémophilie. Les études récentes ou en cours sont mentionnées ci-dessous :

Etudes terminées (résultats en cours)

• PRO-PACT
• HIGS
• CHAVI-014
• ESQUoL

Etudes et projets en cours

• Surveillance Européen (EUHASS) 
• Etude Advance
• ESHB

Regrets liés à la prise en charge des patients et qualité des soins

Ce programme de recherche est composé de 4 étapes:

1. Qu'est-ce que le regret lié à une prise en charge patient ? Est-ce lié toujours lié à une erreur, ou non ? Une étude qualitative a permis d'explorer le vécu des soignants et de comprendre les stratégies mentales de gestion de leurs regrets.

Voir également: Courvoisier DS et al., "Experiencing regrets in clinical practice", The Lancet 2013, 382(9904): 1553-1554 [Pubmed]

2. Comment mesurer le regret lié à une prise en charge patient et les stratégies mentales de gestion des regrets ? Une étude de validation a été conduite afin de construire deux questionnaires, l'un mesurant l'intensité du regret le plus important, l'autre mesurant les stratégies mentales de gestion des regrets quotidiens (publication in press).

Projets en cours:

1) avec la collaboration d'Intermountains Healthcare (Salt Lake City, Utah, Etats-Unis), une étude de validation de la traduction anglaise des deux questionnaires est en cours. Le projet contient trois phases: a) étude qualitative pour adapter culturellement les items du questionnaires, b) traduction des items (backward et forward), c) enquête avec test-retest. Le projet est conduit avec Glen McBride et Pascal Briot.

2) avec la collaboration du Triemli Hospital (Zürich), une étude de validation de la traduction allemande des deux questionnaires est en cours. Le projet est conduit avec Dr. Silvia Richner et Prof. Christoph Meier.

Les prochaines étapes dans le futur seront les suivantes:

3. Comment les regrets influencent la santé mentale des soignants ? (demande de financement en cours d'évaluation)

4. Est-ce qu'une formation aux techniques mentales de gestion des regrets améliore la santé mentale des soignants ?

Implémentation de la checklist chirurgicale de sécurité dans les blocs opératoires en Suisse

En 2010, une enquête par questionnaire a été conduite dans deux congrès de chirurgie en Suisse. 

En 2013, cette enquête sera renouvellée, avec le même questionnaire. Les résultats seront disponibles en hiver 2013.

• Protocoles de recherche en cours
• Publications
• Brochures à l'usage des professionnels

Protocoles de recherche en cours 

GRP78 et BARD1 : Déterminer la valeur de GRP78 et BARD1 comme marqueurs du cancer de l'ovaire.
Investigateurs : Petignat P, Cohen M,
Organisme : Hôpitaux Universitaires de Genève, Projet Recherche et Développement (PRD)
Montant : FRS 100'000.–

Etude de phase III randomisée multicentrique comparant la tolérance et la sécurité de l’association bévacizumab plus paclitaxel à celle de l’association bévacizumab, cyclophosphamide et capécitabine dans le traitement du cancer du sein inopérable ou métastatique.
Organisme : SAKK
Investigateur HUG : Bodmer A.

Etude multicentrique de phase I/II, évaluant la sécurité, la tolérance, la pharmacocinétique et l’efficacité du médicament AZD8931 en association avec le paclitaxel chez des patients et patientes souffrant d’une tumeur solide à un stade avancé et chez des patientes souffrant d’un cancer du sein localement avancé et/ou métastatique avec faible expression du HER2.
Organisme : AstraZeneca
Investigateur HUG : Bodmer A.

Etude AMAROS 10981: "After Mapping Axilla: Radiotherapie Or Surgery". Etude internationale, de phase III, randomisée, "follow-up". En cas de ganglion sentinelle positif: Curage axillaire versus Rx-Thérapie. Follow-up 10 ans.
Organisme: EORTC .
Investigateur principal HUG: P. Petignat

Etude multicentrique de phase III, randomisée, en double aveugle, contrôlée par placebo sur l’évérolimus en association avec le trastuzumab et le paclitaxel dans le traitement de première ligne chez les femmes atteintes d’un cancer du sein localement avancé ou métastatique HER2-positif.
Organisme : Novartis
Investigateur HUG : Bodmer A.

Utilisation d’un anti-transpirant local pour la prévention de l’érythrodysesthésie palmo-plantaire (EPP) chez les patient(e)s traité(e)s avec la doxorubicine liposomale (Caelyx®). Etude multicentrique, de phase III randomisée, en double aveugle
Organisme : SAKK
Investigateur HUG : Bodmer A.

Feasibility and effectiveness of cervical cancer screening at health district level: Pilot project in Baham, West province of Cameroon.
Investigateurs: Petignat P, Tebeu PM
Organisme: Hôpitaux Universitaires de Genève, Projet Recherche et Développement (PRD)
Montant : USD 29'865.-

GRP78 Nouveau Marqueur Diagnostique et Pronostique des Maladies Trophoblastiques.
Investigateurs : Petignat P, Cohen M, Finci V, Epiney M.
Organisme : Hôpitaux Universitaires de Genève, Projet Recherche et Développement (PRD)
Montant : FRS 50'000.-

EORTC 10054 - Etude de Phase I-II de lapatinib et docétaxel en traitement néo-adjuvant chez des patientes ayant un cancer du sein HER-2 positif, localement avancé/inflammatoire ou opérable.
Organisme : EORTC
Investigateur HUG : Nobahar M, Bodmer A

IBIS-II « Prévention » :Etude internationale multicentrique d’anastrazole versus placebo chez les femmes ménopausées à risque accru de cancer du sein.
Organisme : SAKK
Investigateur HUG : Chappuis P, Benusiglio P

IBIS-II « DCIS » : Etude internationale multicentrique randomisée de tamoxifène versus anastrazole chez les femmes ménopausées ayant un cancer canalaire in situ du sein.
Organisme : SAKK
Investigateur HUG : Vlastos G, Chappuis P

PTM : Recherche de modifications post-traductionnelles des protéines sanguines induites par des médicaments
Organisme : HUG
Investigateur HUG : Hochstrasser D

Dépistage prospectif du syndrome de Lynch ou syndrome du cancer colorectal héréditaire non polyposique (HNPCC) dans les populations genevoise et valaisanne
Organisme : OncoSuisse / Ligue contre le cancer
Investigateur HUG : Chappuis P

Publications 

Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model.
Feki A, Berardi P, Bellingan G, Major A, Krause KH, Petignat P, Zehra R, Pervaiz S, Irminger-Finger I.
Crit Rev Oncol Hematol. 2009 Jan 27. [Epub ahead of print]
PMID: 19179094 [PubMed - as supplied by publisher]

Positive Adnexal or Uterine Serosal Involvement in Stage IIIC Endometrial Cancer Is an Adverse Factor for Recurrence.
Hétu V, Petignat P, Wu Y, Drouin P, Sauthier P, Provencher D, Gauthier P.
Gynecol Obstet Invest. 2008 Dec 17;67(3):173-177. [Epub ahead of print]
PMID: 19088481 [PubMed - as supplied by publisher]

Magnetic resonance imaging to identify risk of lymph node metastasis in patients with endometrial cancer.
Undurraga M, Petignat P, Pelte MF, Jacob S, Dubuisson JB, Loubeyre P.
Int J Gynaecol Obstet. 2009 Mar;104(3):233-5. Epub 2008 Nov 25.
PMID: 19036368 [PubMed - in process]

Normal pregnancy or neoplasia?
Rozenholc A, Petignat P.
BMJ. 2008 Oct 29;337:a2107. doi: 10.1136/bmj.a2107. No abstract available.
PMID: 18974041 [PubMed - indexed for MEDLINE]

Is the field of breast imaging moving toward broader use of MR imaging?
Loubeyre P, Petignat P.
Radiology. 2008 Nov;249(2):721; author reply 721-2. No abstract available.
PMID: 18936324 [PubMed - indexed for MEDLINE]

Gynecological malignancies in Maroua, Cameroon.
Tebeu PM, Petignat P, Mhawech-Fauceglia P.
Int J Gynaecol Obstet. 2009 Feb;104(2):148-9. Epub 2008 Oct 15. No abstract available.
PMID: 18926532 [PubMed - indexed for MEDLINE]

Should we modify the current FIGO staging system for early-stage cervical cancer?
Petignat P, Loubeyre P.
Expert Rev Anticancer Ther. 2008 Jul;8(7):1015-7. No abstract available.
PMID: 18588447 [PubMed - indexed for MEDLINE]

Laparoscopy in the management of endometrial cancer
Petignat P, Stucki D, Altermatt HJ, Seydoux J, Jacob S, Brioschi PA, Fink D, Fehr M, Delaloye JF, Loubeyre P, Hohl M, Mueller M, Dubuisson JB.
Rev Med Suisse. 2008 Apr 16;4(153):995-8. French.
PMID: 18549088 [PubMed - indexed for MEDLINE]

Outcome of uterine clear cell carcinomas compared to endometrioid carcinomas and poorly-differentiated endometrioid carcinomas.
Petignat P, Usel M, Gauthier P, Popowski Y, Pelte MF, Bouchardy C, Verkooijen HM.
Eur J Gynaecol Oncol. 2008;29(1):57-60.
PMID: 18386465 [PubMed - indexed for MEDLINE]

What's new in gynecology and obstetrics?
Petignat P, de Tejada MB, Irion O, Boulvain M.
Rev Med Suisse. 2008 Jan 9;4(139):24-7. Review. French.
PMID: 18251211 [PubMed - indexed for MEDLINE]

Diagnosis and management of cervical cancer.
Petignat P, Roy M.
BMJ. 2007 Oct 13;335(7623):765-8. Review. No abstract available.
PMID: 17932207 [PubMed - indexed for MEDLINE]

Advancing women's cancer care
Petignat P, Gotlieb W.
Gynakol Geburtshilfliche Rundsch. 2007;47(4):240-2. No abstract available.
PMID: 17914271 [PubMed - indexed for MEDLINE]

The attitude and knowledge of cervical cancer by Cameroonian women; a clinical survey conducted in Maroua, the capital of Far North Province of Cameroon.
Tebeu PM, Major AL, Rapiti E, Petignat P, Bouchardy C, Sando Z, de Bernis L, Ali L, Mhawech-Fauceglia P.
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):761-5. Epub 2007 Sep 14.
PMID: 17868337 [PubMed - indexed for MEDLINE]

Diagnosis and management of vulvar intraepithelial neoplasias and invasive vulvar cancers
Sauthier P, Petignat P.
Gynakol Geburtshilfliche Rundsch. 2007;47(2):88-93. German.
PMID: 17440270 [PubMed - indexed for MEDLINE]

Are self-collected samples comparable to physician-collected cervical specimens for human papillomavirus DNA testing? A systematic review and meta-analysis.
Petignat P, Faltin DL, Bruchim I, Tramèr MR, Franco EL, Coutlée F.
Gynecol Oncol. 2007 May;105(2):530-5. Epub 2007 Feb 28. Review.
PMID: 17335880 [PubMed - indexed for MEDLINE]

Should intraperitoneal chemotherapy be considered as standard first-line treatment in advanced stage ovarian cancer?
Petignat P, du Bois A, Bruchim I, Fink D, Provencher DM.
Crit Rev Oncol Hematol. 2007 May;62(2):137-47. Epub 2006 Dec 26. Review.
PMID: 17188887 [PubMed - indexed for MEDLINE]

Advancing women's cancer care. Report from the 37th Annual Meeting of the Society of Gynecologic Oncologists, Palm Springs, Calif., USA, March 22-26, 2006.
Mayer Hope J, Bruchim I, Blank SV, Petignat P.
Gynakol Geburtshilfliche Rundsch. 2006;46(4):214-7. No abstract available.
PMID: 17068405 [PubMed - indexed for MEDLINE]

Long-term survival of patients with apparent early-stage (FIGO I-II) epithelial ovarian cancer: a population-based study.
Petignat P, de Weck D, Goffin F, Vlastos G, Obrist R, Luthi JC.
Gynecol Obstet Invest. 2007;63(3):132-6. Epub 2006 Jan 9.
PMID: 17057398 [PubMed - indexed for MEDLINE]

Expression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta.
Petignat P, Laurini R, Goffin F, Bruchim I, Bischof P.
Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1679-84.
PMID: 16884384 [PubMed - indexed for MEDLINE]

Cervical cancer screening: current status and perspectives
Petignat P, Bouchardy C, Sauthier P.
Rev Med Suisse. 2006 May 17;2(66):1308-9, 1311-2. Review. French.
PMID: 16775991 [PubMed - indexed for MEDLINE]

Enhanced detection and typing of human papillomavirus (HPV) DNA in anogenital samples with PGMY primers and the Linear array HPV genotyping test.
Coutlée F, Rouleau D, Petignat P, Ghattas G, Kornegay JR, Schlag P, Boyle S, Hankins C, Vézina S, Coté P, Macleod J, Voyer H, Forest P, Walmsley S; Canadian Women's HIV study Group, Franco E.
J Clin Microbiol. 2006 Jun;44(6):1998-2006.
PMID: 16757590 [PubMed - indexed for MEDLINE]

Chylous ascites after pelvic lymph node dissection for gynecologic cancer.
Williams C, Petignat P, Alobaid A, Provencher D, Gauthier P.
Eur J Surg Oncol. 2007 Apr;33(3):399-400. Epub 2006 May 8. No abstract available.
PMID: 16682167 [PubMed - indexed for MEDLINE]

New aspects in gynecologic oncology.
Petignat P, Alobaid A, Bruchim I, Goffin F.
Gynakol Geburtshilfliche Rundsch. 2006;46(1-2):72-4. No abstract available.
PMID: 16468165 [PubMed - indexed for MEDLINE]

Adjuvant therapy for patients with stage I papillary serous endometrial cancer.
Alobaid A, Bruchim I, Verkooijen H, Gauthier P, Petignat P.
Eur J Surg Oncol. 2006 Apr;32(3):358-62. Epub 2006 Jan 18. Review.
PMID: 16414233 [PubMed - indexed for MEDLINE]

Cervical cancer in pregnant women: laparoscopic evaluation before delaying treatment.
Stan C, Megevand E, Irion O, Wang C, Bruchim I, Petignat P.
Eur J Gynaecol Oncol. 2005;26(6):649-50.
PMID: 16398229 [PubMed - indexed for MEDLINE]

Salvage treatment with high-dose-rate brachytherapy for isolated vaginal endometrial cancer recurrence.
Petignat P, Jolicoeur M, Alobaid A, Drouin P, Gauthier P, Provencher D, Donath D, Van Nguyen T.
Gynecol Oncol. 2006 Jun;101(3):445-9. Epub 2005 Dec 28.
PMID: 16386785 [PubMed - indexed for MEDLINE]

Self-sampling is associated with increased detection of human papillomavirus DNA in the genital tract of HIV-seropositive women.
Petignat P, Hankins C, Walmsley S, Money D, Provencher D, Pourreaux K, Kornegay J, Rouah F, Coutlée F; Canadian Women's HIV Study Group.
Clin Infect Dis. 2005 Aug 15;41(4):527-34. Epub 2005 Jul 14.
PMID: 16028163 [PubMed - indexed for MEDLINE]

Age-related performance of human papillomavirus testing used as an adjunct to cytology for cervical carcinoma screening in a population with a low incidence of cervical carcinoma.
Petignat P, Faltin D, Goffin F, Billieux MH, Stucki D, Sporri S, Vassilakos P.
Cancer. 2005 Jun 25;105(3):126-32.
PMID: 15822123 [PubMed - indexed for MEDLINE]

Treatments patterns of vulvar cancer in the elderly.
Vlastos AT, Usel M, Beffa V, Petignat P, Neyroud-Caspar I, Bouchardy C, Vlastos G.
Surg Oncol. 2004 Dec;13(4):187-91.
PMID: 15615655 [PubMed - indexed for MEDLINE]

Poorer survival of elderly patients with ovarian cancer: a population-based study.
Petignat P, Fioretta G, Verkooijen HM, Vlastos AT, Rapiti E, Bouchardy C, Vlastos G.
Surg Oncol. 2004 Dec;13(4):181-6.
PMID: 15615654 [PubMed - indexed for MEDLINE]

Pre-eclampsia and peripartum cardiomyopathy in molar pregnancy: clinical implication for maternally imprinted genes.
Billieux MH, Petignat P, Fior A, Mhawech P, Blouin JL, Dahoun S, Vassilakos P.
Ultrasound Obstet Gynecol. 2004 Apr;23(4):398-401.
PMID: 15065193 [PubMed - indexed for MEDLINE]

Human chorionic gonadotropin follow-up in patients with molar pregnancy: a time for reevaluation.
Petignat P, Boulvain M, Vassilakos P.
Obstet Gynecol. 2003 Sep;102(3):642-3; author reply 643.
PMID: 12962958 [PubMed - indexed for MEDLINE]

Importance of the general practitioner in the early detection of ovarian cancer.
Petignat P, Joris F, Faltin D.
Gynecol Oncol. 2003 Aug;90(2):491-2. No abstract available.
PMID: 12893228 [PubMed - indexed for MEDLINE]

Is genetic analysis useful in the routine management of hydatidiform mole?
Petignat P, Billieux MH, Blouin JL, Dahoun S, Vassilakos P.
Hum Reprod. 2003 Feb;18(2):243-9. Review.
PMID: 12571156 [PubMed - indexed for MEDLINE]

Why do ovarian cancer patients not consult a gynecologic oncologist?
Petignat P, Vlastos G.
Gynecol Oncol. 2002 Oct;87(1):157; author reply 158. No abstract available.
PMID: 12468361 [PubMed - indexed for MEDLINE]

Are fertility drugs a risk factor for persistent trophoblastic tumour?
Petignat P, Vassilakos P, Campana A.
Hum Reprod. 2002 Jun;17(6):1610-5.
PMID: 12042286 [PubMed - indexed for MEDLINE]

Use of automated primary screening on liquid-based, thin-layer preparations.
Vassilakos P, Carrel S, Petignat P, Boulvain M, Campana A.
Acta Cytol. 2002 Mar-Apr;46(2):291-5.
PMID: 11917575 [PubMed - indexed for MEDLINE]

Primary screening for cervical cancer precursors by the combined use of liquid-based cytology, computer-assisted cytology and HPV DNA testing.
Vassilakos P, Petignat P, Boulvain M, Campana A.
Br J Cancer. 2002 Feb 1;86(3):382-8.
PMID: 11875704 [PubMed - indexed for MEDLINE]

Brochures à l'usage des professionnels 

Brochures disponibles sur le site du GRSSGO

• Fertilité et cancer du sein, éditée en 2008
• Fertilité, cancer de l'ovaire et tumeur borderline de l'ovaire, éditée en 2008
• Fertilité, cancer du col utérin et de l'endomètre, éditée en 2009

• Publications
• Publications internationales

Publications

Hématomes et abrasions cutanées chez la personne âgée 
Tarteaut, M.-H. (2013) Revue francophone de stomathérapie & soins des plaies, 16, 16-17.

Post-traumatic cutaneous hematomas in geriatrics hospital: A neglected disease?
L.Toutous Trellu, F.R. Herrmann, M.-H. Tarteaut, A. Kaya, A. Cheretakis, G. Kaya in Eur Geriatr Med (2012), doi:10.1016/j.eurger.2012.01.05

Cutaneous and subcutaneous hematomas associated with falls in a geriatric hospital.
Toutous Trellu L, Herrmann FR, Tarteaut M-H, Assir N, Kaya A, Cheretakis A, Kaya G in Dermatologica Helvetica - Volume 24(3) - Mars 2012

Cutaneous lumbosacral Herpes Simplex virus among patients hospitalized for an advanced disease.
Toutous-Trellu L, Vantieghem K, Terumalai K, Herrmann F, Piguet V, Kaiser L, Vuagnat H, Zulian G. - J Eur Acad Dermatol Venereol. 2011 May 4. doi: 10.1111/j.1468-3083.2011.04085.x. [Epub ahead of print]

Les chutes, les chocs et les hématomes chez les personnes âgées.
MH Tarteaut, M Chevallier, MC Cueff, L Toutous-Trellu et al in JPC - Journal des Plaies et Cicatrisations; 2010; 75: 30-32 in La revue francophone de Gériatrie et Gérontologie; 2011, 173: 160-162

Indications électives de l’Oxygénothérapie Hyperbare.
Y. Green, J.Y. Berney, - Rev Med Suisse 2009 aug. 19 ; 5(215) ; 1615-8 - Revue médicale Suisse

Dermatoporosis: A chronic cutaneous insufficiency/fragility syndrome. G Kaya, JH Saurat in Dermatology, 2007; 215: 284-294

Major lower limb amputations in elderly observed over ten years : the role of diabetes and peripheral arterial disease.
GA Carmona et al. Diabetes Metab 2005;31:449-54

Morsure de chat et pasteurellose cutanée.
HC Pham, L Toutous-Trellu in Revue médicale Suisse, 2004; N° 2472

Biologie de la cicatrisation et traitement des plaies cutanées.
D Salomon in Dermatologie et Infections sexuellement transmises, 4ème éd, JH Saurat, E Grosshans, P Laugier, JM Lachapelle, 2004 ; p 1035-40

Manifestations cutanées des altérations vasculaires et neurologiques des membres inférieurs.
AA. Ramelet in Dermatologie et Infections sexuellement transmises, 4ème éd, JH Saurat, E Grosshans, P Laugier, JM Lachapelle. 2004. p741-750

Découvertes récentes sur la cicatrisation normale et pathologique.
B. Pittet, S. Vialov, P. Quinodoz, G. Gabbiani, D. Montandon. Méd.Hyg. 55: 2430-2432, 1997.

Covering by a flap induces apoptosis of granulation tissue myofibroblats and vascular cells.
S. Garbin, B. Pittet, D. Montandon, G. Gabbiani, A. Desmoulière. Wound Repair and Regeneration ; 4: 244-251, 1996.

Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren's disease : an open pilot study.
B. Pittet, L. Rubbia, A. Desmoulière, A. P. Sapino, P. Roggero, J. Guerret, J. A. Grimaud, R. Lacher, D. Montandon, G. Gabbiani. Plast. Reconstr. Surg. ; 93:224-235, 1994.

Myofibroblasts from diverse pathologic settings are heterogenous in their content of actine isoforms and intermediate filament proteins.
Skalli, W. Schurch, T. Seemayer, R. Lagace, D. Montandon, B. Pittet-Cuénod and G. Gabbiani. Lab Invest; 60: 275-285, 1989.

Publications internationales

Occlusive vs Gauze Dressings for Local Wound Care in Surgical Patients
A Randomized Clinical Trial
Dirk T. Ubbink, MD, PhD; Hester Vermeulen, RN, PhD; Astrid Goossens, RN, PhD; Raoul B. Kelner, MSc; Sanne M. Schreuder, MSc; Maarten J. Lubbers, MD
(REPRINTED) ARCH SURG/VOL 143 (NO. 10), OCT 2008

The Effects of Different Nutritional Measurements on Delayed Wound
Healing After Hip Fracture in the Elderly
Jiong Jiong Guo, M.D., Huilin Yang, M.D., Ph.D.,1 Haixin Qian, M.D., Lixin Huang, M.D., Ph.D., Zhongxing Guo, M.D., and Tiansi Tang, M.D.
Department of Orthopedics and Department of General Surgery , The First Affiliated Hospital of Soochow University, Suzhou, China - Elsevier -Journal of Surgical Research - 2009 -1–6

Topical silver for treating infected wounds (Review)
Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT Copyright © 2009 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd.

Prospective Evaluation of Occlusive Hydrocolloid Dressing Versus Conventional Gauze Dressing Regarding the Healing Effect After Abdominal - Operations: Randomized Controlled Trial
Tetsuo Shinohara, Yuichi Yamashita, Keiichi Satoh, Koji Mikami, Yasushi Yamauchi, Seiichirou Hoshino, Akinori Noritomi and Takahumi Maekawa,
Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka, Japan. ASIAN JOURNAL OF SURGERY VOL 31 • NO 1 • JANUARY 2008

Topical negative pressure for treating chronic wounds (Review)
Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H Copyright © 2009 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd.

Effect of Three Wound Dressings on Infection, Healing Comfort, and Cost in Patients With Sternotomy Wounds* A Randomized Trial
Rochelle Wynne, RN, MEd; Mari Botti, RN, PhD; Hilary Stedman, RN; Lynda Holsworth, RN, BN (Hons); Maria Harinos, RN, BN; Olivia Flavell, RN, BN; and Christianne Manterfield, RN, BN Chest 2004;125; 43-49 - This information is current as of November 9, 2009